Weinstock Martin A, Still Joanne M
Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Semin Cutan Med Surg. 2011 Dec;30(4 Suppl):S10-3. doi: 10.1016/j.sder.2011.11.004.
Skin cancers are the most common form of malignancy, and basal cell carcinoma (BCC) is the most common form of skin cancer. BCCs generally occur sporadically and either singly or in small numbers. When detected and treated early, these tumors are highly curable. When therapy is chosen that is appropriate to the subtype and anatomic location of the lesion, the recurrence rate typically is low. Tumors that are recurrent, aggressive, unresectable, advanced, and/or metastatic are more difficult to treat successfully, as are the multiple BCCs that occur commonly in patients with the genodermatosis known as Gorlin syndrome (also called basal cell nevus syndrome or nevoid basal cell carcinoma syndrome). For these difficult-to-manage patients, the hope for the future lies in chemoprevention.
皮肤癌是最常见的恶性肿瘤形式，而基底细胞癌（BCC）是最常见的皮肤癌类型。基底细胞癌通常散发性出现，可为单个或少数几个。如果早期发现并治疗，这些肿瘤具有很高的治愈率。当选择适合病变亚型和解剖位置的治疗方法时，复发率通常较低。复发性、侵袭性、不可切除、晚期和/或转移性肿瘤更难以成功治疗，患有遗传性皮肤病戈林综合征（也称为基底细胞痣综合征或痣样基底细胞癌综合征）的患者中常见的多发性基底细胞癌也是如此。对于这些难以管理的患者，未来的希望在于化学预防。
