生物黄酮 A（一种大豆异黄酮）对链脲佐菌素诱导的糖尿病大鼠的降血糖作用。
Antihyperglycemic effect of biochanin A, a soy isoflavone, on streptozotocin-diabetic rats.
机构信息
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India.
出版信息
Eur J Pharmacol. 2012 Feb 15;676(1-3):89-94. doi: 10.1016/j.ejphar.2011.11.051. Epub 2011 Dec 8.
The study was designed to investigate the antihyperglycemic effect of biochanin A on streptozotocin-diabetic rats. Diabetes was induced in adult male albino rats of the Wistar strain, weighing 180-200 g, by administration of streptozotocin (40 mg/kg of body weight) intraperitoneally. Diabetic rats showed increase in plasma glucose and glycosylated hemoglobin and a decrease in plasma insulin and hemoglobin. Activities of gluconeogenic enzymes such as glucose 6-phosphatase, fructose 1,6-bisphosphatase increased and glucokinase, glucose 6-phosphate dehydrogenase decreased in the liver of diabetic rats along with glycogen. Oral administration of biochanin A (10mg/kg body weight) or glibenclamide (600 μg/kg body weight) in 0.5% dimethyl sulfoxide, for 45 days, prevented the above changes and improved towards normality. In addition, protection against body weight loss of diabetic animals by biochanin A was also observed. No significant effect was observed in normal rats treated with biochanin A (10mg/kg bodyweight). These results showed that biochanin A has potential antihyperglycemic activity at a dose of 10mg/kg bodyweight in streptozotocin induced diabetic rats.
本研究旨在探讨大豆苷元对链脲佐菌素诱导的糖尿病大鼠的降血糖作用。通过腹腔注射链脲佐菌素（40mg/kg 体重），诱导成年雄性白化 Wistar 大鼠产生糖尿病。糖尿病大鼠的血浆葡萄糖和糖化血红蛋白升高，而血浆胰岛素和血红蛋白降低。糖尿病大鼠肝脏中的糖异生酶活性如葡萄糖 6-磷酸酶、果糖 1,6-二磷酸酶升高，而肝激酶、葡萄糖 6-磷酸脱氢酶降低，同时伴随着糖原的减少。在 0.5%二甲基亚砜中，以 10mg/kg 体重的剂量口服大豆苷元或格列本脲（600μg/kg 体重），连续 45 天，可预防上述变化，并使情况向正常化改善。此外，还观察到大豆苷元对糖尿病动物体重减轻的保护作用。正常大鼠用大豆苷元（10mg/kg 体重）治疗未观察到显著影响。这些结果表明，大豆苷元在链脲佐菌素诱导的糖尿病大鼠中，以 10mg/kg 体重的剂量具有潜在的降血糖活性。
Zotero 插件