Palsamy P, Subramanian S
Research Scholar, Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, Tamilnadu, India.
Chem Biol Interact. 2009 May 15;179(2-3):356-62. doi: 10.1016/j.cbi.2008.11.008. Epub 2008 Nov 19.
Resveratrol, a ubiquitous stress-induced phytoalexin, has demonstrated a wide variety of biological activities which make it a good candidate for the treatment of diabetes mellitus. The present study was aimed to evaluate its therapeutic potential by assaying the activities of key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. The daily oral treatment of resveratrol (5 mg/kg body weight) to diabetic rats for 30 days demonstrated a significant (p<0.05) decline in blood glucose and glycosylated hemoglobin levels and a significant (p<0.05) increase in plasma insulin level. The altered activities of the key enzymes of carbohydrate metabolism such as hexokinase, pyruvate kinase, lactate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, glucose-6-phosphate dehydrogenase, glycogen synthase and glycogen phosphorylase in liver and kidney tissues of diabetic rats were significantly (p<0.05) reverted to near normal levels by the administration of resveratrol. Further, resveratrol administration to diabetic rats improved hepatic glycogen content suggesting the antihyperglycemic potential of resveratrol in diabetic rats. The obtained results were compared with glyclazide, a standard oral hypoglycemic drug. Thus, the modulatory effects of resveratrol on attenuating these enzymes activities afford a promise for widespread use for treatment of diabetes in the future.
白藜芦醇是一种普遍存在的应激诱导植物抗毒素，已显示出多种生物活性，这使其成为治疗糖尿病的良好候选药物。本研究旨在通过检测链脲佐菌素-烟酰胺诱导的糖尿病大鼠碳水化合物代谢关键酶的活性来评估其治疗潜力。对糖尿病大鼠每日口服白藜芦醇（5毫克/千克体重），持续30天，结果显示血糖和糖化血红蛋白水平显著（p<0.05）下降，血浆胰岛素水平显著（p<0.05）升高。糖尿病大鼠肝和肾组织中碳水化合物代谢关键酶如己糖激酶、丙酮酸激酶、乳酸脱氢酶、葡萄糖-6-磷酸酶、果糖-1,6-二磷酸酶、葡萄糖-6-磷酸脱氢酶、糖原合酶和糖原磷酸化酶的活性改变，通过给予白藜芦醇显著（p<0.05）恢复到接近正常水平。此外，给糖尿病大鼠施用白藜芦醇可提高肝糖原含量，表明白藜芦醇对糖尿病大鼠具有降血糖潜力。将所得结果与标准口服降糖药格列齐特进行比较。因此，白藜芦醇对这些酶活性的调节作用为未来广泛用于治疗糖尿病带来了希望。
