Electrophilic levuglandin E2-protein adducts bind glycine: a model for protein crosslinking.
作者信息
Jirousek M R, Murthi K K, Salomon R G
机构信息
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106-2699.
出版信息
Prostaglandins. 1990 Aug;40(2):187-203. doi: 10.1016/0090-6980(90)90083-8.
PMID:2217833
Abstract
Prevention by glycine of protein crosslinking which accompanies binding of levuglandin E2 (LGE2) is shown to involve binding of glycine with the protein-LGE2 adduct. With ovalbumin, the LGE2 adduct initially binds nearly 2 equivalents of glycine, but the capacity to bind glycine decreases with time reflecting a competition, inter alia, with crosslinking.
摘要
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