Barter P J, Lally J I, Wattchow D
Metabolism. 1979 Jun;28(6):614-8. doi: 10.1016/0026-0495(79)90012-x.
The metabolism of triglyceride in the plasma low density lipoproteins (LDL) and high density lipoproteins (HDL) was studied in the normal-fed rabbit. Preparations of LDL and HDL la-eled with 3H in the triglyceride moiety were obtained from donor rabbits that had previously been injected with 3H-palmitic acid. These labeled lipoproteins were subsequently either reinjected into other rabbits or incubated in vitro with unlabeled lipoprotein fractions. In vivo, there were bidirectional transfers of 3H-triglyceride between the LDL and HDL, the rate of which considerably exceeded that of any irreversible removal from the plasma compartment. To a much lesser extent, there was also a transfer of 3H-triglyceride from both LDL and HDL to very low density lipoproteins (VLDL). In vitro, so long as the dialysed 1.21 g/ml infranate of serum was present there was a significant transfer of 3H-triglyceride from both LDL and HDL into each of the other lipoprotein fractions that in no case could be accounted for by a corresponding net transfer of triglyceride mass. It was concluded that the pools of triglyceride in LDL and HDL, and to a lesser extent in VLDL, comprise parts of a larger, progressively equilibrating pool.
在正常喂食的家兔中研究了血浆低密度脂蛋白（LDL）和高密度脂蛋白（HDL）中甘油三酯的代谢。从先前注射过3H-棕榈酸的供体家兔中获得甘油三酯部分用3H标记的LDL和HDL制剂。这些标记的脂蛋白随后要么重新注射到其他家兔体内，要么与未标记的脂蛋白组分在体外孵育。在体内，LDL和HDL之间存在3H-甘油三酯的双向转移，其速率大大超过了从血浆区室的任何不可逆清除的速率。在小得多的程度上，3H-甘油三酯也从LDL和HDL转移到极低密度脂蛋白（VLDL）。在体外，只要存在透析后的血清1.21 g/ml下层清液，3H-甘油三酯就会从LDL和HDL大量转移到其他每个脂蛋白组分中，而在任何情况下这都不能由甘油三酯质量的相应净转移来解释。得出的结论是，LDL和HDL中的甘油三酯池，以及在较小程度上VLDL中的甘油三酯池，构成了一个更大的、逐渐平衡的池的一部分。
