新型分子深入了解 CETP 结构与功能：综述
New molecular insights into CETP structure and function: a review.
机构信息
Department of Medicine University of California, San Francisco, CA 94158, USA.
出版信息
J Lipid Res. 2012 Aug;53(8):1451-8. doi: 10.1194/jlr.R027011. Epub 2012 Jun 7.
Abstract
Cholesteryl ester transfer protein (CETP) is important clinically and is the current target for new drug development. Its structure and mechanism of action has not been well understood. We have combined current new structural and functional methods to compare with relevant prior data. These analyses have led us to propose several steps in CETP's function at the molecular level, in the context of its interactions with lipoproteins, e.g., sensing, penetration, docking, selectivity, ternary complex formation, lipid transfer, and HDL dissociation. These new molecular insights improve our understanding of CETP's mechanisms of action.
摘要
胆固醇酯转移蛋白（CETP）在临床上很重要，是新药开发的当前靶点。其结构和作用机制尚未得到很好的理解。我们结合了当前新的结构和功能方法，并与相关的先前数据进行了比较。这些分析使我们提出了 CETP 在与脂蛋白相互作用时，分子水平上的几个功能步骤，例如感应、穿透、对接、选择性、三元复合物形成、脂质转移和 HDL 解离。这些新的分子见解提高了我们对 CETP 作用机制的理解。
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