School of Pharmacy and Biomolecular Science, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK.
Adv Drug Deliv Rev. 2012 Apr;64(5):422-30. doi: 10.1016/j.addr.2011.12.001. Epub 2011 Dec 11.
Conventional rate Differential Scanning Calorimetry (DSC) has been used for many years as a tool in the analysis of pharmaceutical materials. In recent years an extension of the technique to include fast heating and cooling rates has become more prevalent. Broadly termed Fast-Scan DSC, this review examines the current applications of this technique to the characterisation and selection of pharmaceutical materials. Its increasing use encompasses the characterisation of amorphousness in crystalline materials, the characterisation of polymorphs and polymorphic transitions, the solubility of drugs in polymers, and characterisation of dosage forms. Notwithstanding the advantages of analytical speed in analytical turnover, the review emphasises the advantages of Fast-Scan DSC in its sensitivity which allows the separation of overlapping thermal events, the reduction it provides in degradation during the scanning process and its role in determining solubility in waxy and polymeric based systems. A comparison of the uses of Fast-Scan DSC to modulated DSC techniques and localised thermal analysis is also given.
传统的差示扫描量热法（DSC）多年来一直被用作分析药物材料的工具。近年来，该技术的扩展包括更快的加热和冷却速率变得更加普遍。广义上称为快速扫描 DSC，本综述考察了该技术在药物材料的特性和选择方面的当前应用。它的使用越来越广泛，包括对结晶材料无定形性的表征、多晶型和多晶型转变的表征、药物在聚合物中的溶解度的表征以及剂型的表征。尽管在分析周转率方面具有分析速度的优势，但综述强调了快速扫描 DSC 的灵敏度优势，该优势允许分离重叠的热事件，减少扫描过程中的降解，并在确定蜡质和聚合物基系统中的溶解度方面发挥作用。还比较了快速扫描 DSC 与调制 DSC 技术和局部热分析的用途。
