Division of Clinical Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA.
Biol Psychol. 2012 Feb;89(2):408-15. doi: 10.1016/j.biopsycho.2011.12.003. Epub 2011 Dec 15.
Psychopathy is a constellation of self-serving attitudes and antisocial behaviors with little regard to cost to self and others. Might this symptomatology arise in part from an exaggerated response of brain motivational circuitry to prospective rewards? We examined whether psychopathic tendencies are associated with increased recruitment of incentive neurocircuitry during anticipation of instrumental and conditioned rewards. Healthy controls completed the Psychopathic Personality Inventory (PPI), then were presented with response-contingent and passively delivered rewards during functional MRI. PPI scores correlated negatively with reaction time to incentivized targets, but not with reaction time to non-incentivized targets. PPI scores also correlated positively with recruitment of ventral striatum and anterior cingulate cortex during instrumental reward anticipation. PPI scores also correlated with middle frontal cortex recruitment during anticipation of passively received rewards. These data indicate that in psychiatrically healthy controls, individuals with greater endorsement of psychopathic tendencies show more robust neurophysiological and behavioral signatures of incentive motivation.
精神病态是一种自我服务的态度和反社会行为的组合，很少考虑到对自己和他人的代价。这种症状是否部分源于大脑动机回路对预期奖励的反应过度？我们研究了精神病态倾向是否与在预期工具性和条件性奖励时激励神经回路的招募增加有关。健康对照组完成了精神病态人格量表（PPI），然后在功能磁共振成像期间接受了反应相关和被动给予的奖励。PPI 评分与激励性目标的反应时间呈负相关，但与非激励性目标的反应时间无关。PPI 评分还与工具性奖励预期期间腹侧纹状体和前扣带皮层的募集呈正相关。PPI 评分也与被动接受奖励时的中额叶皮层募集呈正相关。这些数据表明，在精神健康对照组中，精神病态倾向越强的个体表现出更强的激励动机的神经生理和行为特征。
