Department of Surgery, Division of Surgical Oncology, Winship Cancer Institute, Emory University, 1365 Clifton Road, North East, Suite C2004, Atlanta, GA 30322, USA.
Am J Surg. 2012 Jun;203(6):761-7. doi: 10.1016/j.amjsurg.2011.04.008. Epub 2011 Dec 16.
Cutaneous malignancies in the pediatric population are rare. Melanocytic neoplasms have garnered increased attention as the incidence of melanoma rises and as published analyses of biologically indeterminate lesions become more commonplace. Pediatric melanomas have been studied in several large cohort series; still, most of our assumptions for treatment stems from research in the adult population. Many clinicians speculate that pediatric melanomas may be biologically different from the same histological entity in adults given observed differences in metastatic potential and overall outcomes in children. Even more confounding are the atypical spitzoid lesions, which continue to spark debate in the oncology and dermatopathology literature with respect to classification, malignant potential, and recommended treatment course. In this article, recent literature addressing both atypical spitzoid melanocytic neoplasms and melanoma in the pediatric population is discussed.
儿童人群中的皮肤恶性肿瘤较为罕见。随着黑色素瘤发病率的上升，以及对生物学不确定病变的分析越来越普遍，黑素细胞肿瘤受到了更多的关注。已经有几项大型队列研究对儿童黑色素瘤进行了研究；但是，我们对治疗的大多数假设都源于对成人的研究。许多临床医生推测，由于儿童的转移潜力和总体预后与成人存在差异，因此儿童的黑色素瘤可能在生物学上与成人的同一组织学实体不同。更复杂的是，具有非典型 Spitz 样特征的病变，在肿瘤学和皮肤病理文献中继续引发争议，涉及分类、恶性潜能以及推荐的治疗方案。本文讨论了最近有关儿童人群中的非典型 Spitz 样黑素细胞肿瘤和黑色素瘤的文献。
