Guernsey D L, Morishige W K
Metabolism. 1979 Jun;28(6):629-32. doi: 10.1016/0026-0495(79)90015-5.
A dramatic reduction in ouabain-sensitive tissue respiration of obese mouse muscle and liver was observed, suggesting that Na+-transport-dependent calorigenesis is impaired in these animals. Additionally, a significantly depressed nuclear triiodothyronine binding capacity in liver and lung tissue was exhibited by obese mice. These data support the suggestion that the hypometabolism and hypothermia of the genetically obese mouse is a result of reduced Na+-pump-related thermogenesis; and further, provides evidence that this may be the consequence of reduced nuclear binding of triiodothyronine.
观察到肥胖小鼠肌肉和肝脏哇巴因敏感的组织呼吸显著降低，这表明这些动物中依赖钠转运的产热过程受损。此外，肥胖小鼠的肝脏和肺组织中核三碘甲状腺原氨酸结合能力显著降低。这些数据支持以下观点：遗传性肥胖小鼠的代谢减退和体温过低是钠泵相关产热减少的结果；而且，这进一步证明这可能是三碘甲状腺原氨酸核结合减少的后果。
