在甲状腺功能亢进大鼠的肝细胞中，（钠+钾）依赖性三磷酸腺苷酶没有明显的主要产热作用。
No major thermogenic role for (Na+ + K+)-dependent adenosine triphosphatase apparent in hepatocytes from hyperthyroid rats.
作者信息
Clark D G, Brinkman M, Filsell O H, Lewis S J, Berry M N
出版信息
Biochem J. 1982 Mar 15;202(3):661-5. doi: 10.1042/bj2020661.
Abstract
(Na+ + K+)-dependent ATPase activity, heat production and oxygen consumption were increased by 59%, 62% and 75% respectively in hepatocytes from tri-iodothyronine-treated rats. Ouabain at concentrations of 1 and 10 mM decreased oxygen uptake by 2--8% in hepatocytes from euthyroid rats and by 5--15% in hepatocytes from hyperthyroid animals. Heat output was decreased by 4--9% with the glycoside in isolated liver parenchymal cells from the control animals and by 11% in the cells from the tri-iodothyronine-treated animals. These results do not support the hypothesis that hepatic (Na+ + K+)-ATPase plays a major role in increased heat production in hepatocytes from hyperthyroid rats.
摘要
在经三碘甲状腺原氨酸处理的大鼠的肝细胞中，（钠 + 钾）依赖性ATP酶活性、产热和耗氧量分别增加了59%、62%和75%。浓度为1和10 mM的哇巴因使正常甲状腺大鼠肝细胞的氧摄取减少2 - 8%，使甲状腺功能亢进动物肝细胞的氧摄取减少5 - 15%。在对照动物分离的肝实质细胞中，糖苷使热量输出减少4 - 9%，在经三碘甲状腺原氨酸处理的动物细胞中减少11%。这些结果不支持肝（钠 + 钾）-ATP酶在甲状腺功能亢进大鼠肝细胞产热增加中起主要作用这一假说。
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