Wong Y F, Loong E P, Mao K R, Tam P P, Panesar N S, Neale E, Chang A M
Department of Obstetrics and Gynaecology, Faculty of Medicine, Chinese University of Hong Kong.
Reprod Fertil Dev. 1990;2(4):351-8. doi: 10.1071/rd9900351.
Salivary oestradiol (E2) and progesterone (P) levels have been shown to reflect the biologically active fractions in the serum. The luteal-phase status of stimulated cycles was investigated after in vitro fertilization and embryo transfer (IVF-ET). Thirty patients were randomly allocated to one of three luteal therapy groups: group A had no support, group B had intramuscular P and group C had intramuscular P and human chorionic gonadotrophin (hCG). One pregnancy was achieved in group A, two in group B and three in group C. Significant correlations between salivary and serum levels of E2 and of P in matched samples during luteal phase were found. Salivary E2 levels from luteal day 8 through day 14 and P levels from day 3 through day 14 were significantly higher in the pregnant than in the nonpregnant cycles. Among the nonpregnant cycles, salivary E2 and P levels were significantly higher in group C than in group A or B. These findings suggest that, in stimulated cycles for IVF-ET, determination of salivary E2 and P levels may be used as reliable alternatives to serum concentrations for assessing the luteal phase. Also, the additional hCG has an enhanced luteotrophic effect, as reflected by the higher salivary E2 and P levels, which may lead to a better pregnancy rate.
唾液雌二醇（E2）和孕酮（P）水平已被证明可反映血清中的生物活性成分。在体外受精和胚胎移植（IVF-ET）后，对刺激周期的黄体期状态进行了研究。30名患者被随机分配到三个黄体期治疗组之一：A组不给予支持，B组给予肌肉注射P，C组给予肌肉注射P和人绒毛膜促性腺激素（hCG）。A组有1例妊娠，B组有2例，C组有3例。发现在黄体期匹配样本中，唾液和血清E2及P水平之间存在显著相关性。妊娠周期中，黄体期第8天至第14天的唾液E2水平以及第3天至第14天的P水平显著高于未妊娠周期。在未妊娠周期中，C组的唾液E2和P水平显著高于A组或B组。这些发现表明，在IVF-ET的刺激周期中，测定唾液E2和P水平可作为评估黄体期血清浓度的可靠替代方法。此外，额外添加的hCG具有增强的黄体营养作用，这通过较高的唾液E2和P水平得以体现，这可能会导致更高的妊娠率。
