Bortner Carl D, Cidlowski John A
The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
Cell Physiol Biochem. 2011;28(6):1079-88. doi: 10.1159/000335864. Epub 2011 Dec 16.
The loss of cell volume, termed apoptotic volume decrease (AVD) has been a hallmark feature of apoptosis. However the role of this characteristic attribute of programmed cell death has always been questioned as to whether it plays an active or passive factor during apoptosis. Here we review studies that suggest that AVD plays an active role during apoptosis and the underlying flux of ions that results in this morphological event regulates the programmed cell death process.
细胞体积的丧失，即凋亡性体积减小（AVD），一直是细胞凋亡的一个标志性特征。然而，程序性细胞死亡这一特征属性的作用，即在细胞凋亡过程中它是发挥主动还是被动作用，一直受到质疑。在此，我们综述了一些研究，这些研究表明AVD在细胞凋亡过程中发挥着积极作用，并且导致这一形态学事件的潜在离子通量调节着程序性细胞死亡过程。
