淋巴细胞的生死：一个体积调节问题。
Life and death of lymphocytes: a volume regulation affair.
作者信息
Bortner Carl D, Cidlowski John A
机构信息
The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
出版信息
Cell Physiol Biochem. 2011;28(6):1079-88. doi: 10.1159/000335864. Epub 2011 Dec 16.
Abstract
The loss of cell volume, termed apoptotic volume decrease (AVD) has been a hallmark feature of apoptosis. However the role of this characteristic attribute of programmed cell death has always been questioned as to whether it plays an active or passive factor during apoptosis. Here we review studies that suggest that AVD plays an active role during apoptosis and the underlying flux of ions that results in this morphological event regulates the programmed cell death process.
摘要
细胞体积的丧失，即凋亡性体积减小（AVD），一直是细胞凋亡的一个标志性特征。然而，程序性细胞死亡这一特征属性的作用，即在细胞凋亡过程中它是发挥主动还是被动作用，一直受到质疑。在此，我们综述了一些研究，这些研究表明AVD在细胞凋亡过程中发挥着积极作用，并且导致这一形态学事件的潜在离子通量调节着程序性细胞死亡过程。
相似文献
1
Life and death of lymphocytes: a volume regulation affair.淋巴细胞的生死：一个体积调节问题。
Cell Physiol Biochem. 2011;28(6):1079-88. doi: 10.1159/000335864. Epub 2011 Dec 16.
2
Cell volume regulation in immune cell apoptosis.免疫细胞凋亡中的细胞体积调节
Cell Tissue Res. 2000 Jul;301(1):33-42. doi: 10.1007/s004410000216.
3
Osmotic stress resistance imparts acquired anti-apoptotic mechanisms in lymphocytes.渗透胁迫抗性赋予淋巴细胞获得性抗细胞凋亡机制。
J Biol Chem. 2012 Feb 24;287(9):6284-95. doi: 10.1074/jbc.M111.293001. Epub 2012 Jan 6.
4
Prerequisite role of persistent cell shrinkage in apoptosis of human epithelial cells.持续性细胞皱缩在人上皮细胞凋亡中的先决作用。
Sheng Li Xue Bao. 2007 Aug 25;59(4):512-6.
5
Volume-sensitive chloride channels (ICl,vol) mediate doxorubicin-induced apoptosis through apoptotic volume decrease in cardiomyocytes.容积敏感性氯通道（ICl,vol）通过心肌细胞凋亡性容积减小介导阿霉素诱导的细胞凋亡。
Fundam Clin Pharmacol. 2004 Oct;18(5):531-8. doi: 10.1111/j.1472-8206.2004.00273.x.
6
Cytoplasmic condensation is both necessary and sufficient to induce apoptotic cell death.细胞质浓缩对于诱导凋亡性细胞死亡而言既是必要的也是充分的。
J Cell Sci. 2008 Feb 1;121(Pt 3):290-7. doi: 10.1242/jcs.017343. Epub 2008 Jan 15.
7
Apoptotic volume decrease as a geometric determinant for cell dismantling into apoptotic bodies.凋亡体积减小是细胞解体为凋亡小体的几何决定因素。
Cell Death Differ. 2010 Nov;17(11):1665-71. doi: 10.1038/cdd.2010.96. Epub 2010 Aug 13.
8
Assessment of apoptosis in xenobiotic-induced immunotoxicity.外源性物质诱导的免疫毒性中细胞凋亡的评估。
Methods. 1999 Sep;19(1):36-47. doi: 10.1006/meth.1999.0825.
9
10
Caspase independent/dependent regulation of K(+), cell shrinkage, and mitochondrial membrane potential during lymphocyte apoptosis.淋巴细胞凋亡过程中半胱天冬酶非依赖性/依赖性对钾离子、细胞皱缩和线粒体膜电位的调节
J Biol Chem. 1999 Jul 30;274(31):21953-62. doi: 10.1074/jbc.274.31.21953.
引用本文的文献
1
UVC-Protective Activity of Lemongrass Among 12 Fat-soluble Herbal Extracts: Rapid Decay Due to Cytotoxicity.柠檬草等 12 种脂溶性草药提取物的 UVC 防护活性：因细胞毒性而迅速衰减。
In Vivo. 2023 Nov-Dec;37(6):2464-2472. doi: 10.21873/invivo.13353.
2
Cancer as a Channelopathy-Appreciation of Complimentary Pathways Provides a Different Perspective for Developing Treatments.癌症作为一种通道病——对互补途径的认识为开发治疗方法提供了不同的视角。
Cancers (Basel). 2022 Sep 23;14(19):4627. doi: 10.3390/cancers14194627.
3
Ion Channels Orchestrate Pancreatic Ductal Adenocarcinoma Progression and Therapy.离子通道调控胰腺导管腺癌的进展与治疗。
Front Pharmacol. 2021 Jan 19;11:586599. doi: 10.3389/fphar.2020.586599. eCollection 2020.
4
Relevance and Regulation of Cell Density.细胞密度的相关性和调控
Trends Cell Biol. 2020 Mar;30(3):213-225. doi: 10.1016/j.tcb.2019.12.006. Epub 2020 Jan 21.
5
Stage-Specific Changes in the Water, Na+, Cl- and K+ Contents of Organelles during Apoptosis, Demonstrated by a Targeted Cryo Correlative Analytical Approach.通过靶向冷冻相关分析方法揭示凋亡过程中细胞器水、Na⁺、Cl⁻和K⁺含量的阶段特异性变化。
PLoS One. 2016 Feb 11;11(2):e0148727. doi: 10.1371/journal.pone.0148727. eCollection 2016.
6
Temporal Heterogeneity Metrics in Apoptosis Induced by Anticancer Drugs.抗癌药物诱导凋亡中的时间异质性指标
J Histochem Cytochem. 2015 Jul;63(7):494-510. doi: 10.1369/0022155415583534. Epub 2015 Apr 2.
7
Epoxyeicosatrienoic acids attenuating hypotonic-induced apoptosis of IMCD cells via γ-ENaC inhibition.
PLoS One. 2014 Apr 8;9(4):e94400. doi: 10.1371/journal.pone.0094400. eCollection 2014.
8
Ion channels and apoptosis in cancer.癌症中的离子通道与细胞凋亡
Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130104. doi: 10.1098/rstb.2013.0104. Print 2014 Mar 19.
9
The sigma-1 receptor: a regulator of cancer cell electrical plasticity?sigma-1 受体：癌细胞电可塑性的调节因子？
Front Physiol. 2013 Jul 16;4:175. doi: 10.3389/fphys.2013.00175. eCollection 2013.
10
Phosphatidylserine exposure during apoptosis reflects bidirectional trafficking between plasma membrane and cytoplasm.细胞凋亡过程中磷脂酰丝氨酸的暴露反映了质膜和细胞质之间的双向转运。
Cell Death Differ. 2013 Jan;20(1):64-76. doi: 10.1038/cdd.2012.93. Epub 2012 Aug 3.
本文引用的文献
1
Multiparametric analysis of apoptosis by flow cytometry.通过流式细胞术对细胞凋亡进行多参数分析。
Methods Mol Biol. 2011;699:203-27. doi: 10.1007/978-1-61737-950-5_10.
2
Ion transport in a human lens epithelial cell line exposed to hyposmotic and apoptotic stress.低渗和凋亡应激下人晶状体上皮细胞系中的离子转运。
J Cell Physiol. 2010 Apr;223(1):110-22. doi: 10.1002/jcp.22015.
3
Inhibition of protein kinase Akt1 by apoptosis signal-regulating kinase-1 (ASK1) is involved in apoptotic inhibition of regulatory volume increase.凋亡信号调节激酶 1（ASK1）抑制蛋白激酶 Akt1 参与调节体积增加的凋亡抑制。
J Biol Chem. 2010 Feb 26;285(9):6109-17. doi: 10.1074/jbc.M109.072785. Epub 2010 Jan 4.
4
Reactive oxygen species, cellular redox systems, and apoptosis.活性氧、细胞氧化还原系统与细胞凋亡。
Free Radic Biol Med. 2010 Mar 15;48(6):749-62. doi: 10.1016/j.freeradbiomed.2009.12.022. Epub 2010 Jan 4.
5
Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: role of chloride channels.多药耐药肿瘤细胞凋亡体积减小和离子运动的去调控：氯离子通道的作用。
Am J Physiol Cell Physiol. 2010 Jan;298(1):C14-25. doi: 10.1152/ajpcell.00654.2008. Epub 2009 Oct 21.
6
Apoptosis and glutathione: beyond an antioxidant.细胞凋亡与谷胱甘肽：超越抗氧化剂的作用
Cell Death Differ. 2009 Oct;16(10):1303-14. doi: 10.1038/cdd.2009.107. Epub 2009 Aug 7.
7
Physiology of cell volume regulation in vertebrates.脊椎动物细胞体积调节的生理学
Physiol Rev. 2009 Jan;89(1):193-277. doi: 10.1152/physrev.00037.2007.
8
Glutathione depletion and disruption of intracellular ionic homeostasis regulate lymphoid cell apoptosis.谷胱甘肽耗竭和细胞内离子稳态破坏调节淋巴细胞凋亡。
J Biol Chem. 2008 Dec 26;283(52):36071-87. doi: 10.1074/jbc.M807061200. Epub 2008 Oct 21.
9
Glutathione and apoptosis.谷胱甘肽与细胞凋亡
Free Radic Res. 2008 Aug;42(8):689-706. doi: 10.1080/10715760802317663.
10
An endogenous calcium-dependent, caspase-independent intranuclear degradation pathway in thymocyte nuclei: antagonism by physiological concentrations of K(+) ions.胸腺细胞核内一种内源性钙依赖性、半胱天冬酶非依赖性的核内降解途径：生理浓度钾离子的拮抗作用
Exp Cell Res. 2008 Apr 1;314(6):1237-49. doi: 10.1016/j.yexcr.2007.12.028. Epub 2008 Jan 16.
Zotero 插件