肝细胞石蜡 1 抗原作为 Barrett 食管早期诊断的生物标志物。
Hepatocyte paraffin 1 antigen as a biomarker for early diagnosis of Barrett esophagus.
机构信息
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, USA.
出版信息
Am J Clin Pathol. 2012 Jan;137(1):111-20. doi: 10.1309/AJCPYOBVGS4CGA8Y.
We evaluated hepatocyte paraffin 1 (HepPar1) antigen expression, a sensitive marker of small intestinal differentiation, in combination with morphologic features to demonstrate intestinal differentiation in cases equivocal for Barrett esophagus (BE). Clinicopathologic features and HepPar1 expression were recorded for 54 BE cases, 45 consistent with reflux esophagitis (RE) cases, and 65 "suspicious" for BE (SBE) cases. The SBE category included RE cases with 2 or more morphologic changes associated with BE or metaplastic reaction to injury (eg, multilayered epithelium, squamous islands, goblet cell mimickers, pancreatic metaplasia). HepPar1 was expressed in all 54 BE cases, 4 of 45 RE cases, and 24 of 65 SBE cases. In SBE cases, 2 or more morphologic changes were associated with HepPar1 expression in 37% of cases (24/65), 3 or more features in 59% (13/22), and 4 or more features in 100% (4/4) (P ≤ .004). The combination of certain morphologic changes and HepPar1 expression in clinically suspicious distal esophageal biopsy cases without goblet cells supports the presence of evolving intestinal metaplasia.
我们评估了肝石蜡 1 （HepPar1）抗原表达，这是一种对小肠分化敏感的标志物，结合形态学特征来证明 Barrett 食管（BE）不明确病例中的肠分化。记录了 54 例 BE 病例、45 例与反流性食管炎（RE）相符的病例和 65 例“可疑”BE（SBE）病例的临床病理特征和 HepPar1 表达情况。SBE 类别包括 2 个或更多与 BE 相关的形态变化或损伤的化生反应（例如，多层上皮、鳞状岛、杯状细胞模拟物、胰腺化生）的 RE 病例。HepPar1 在所有 54 例 BE 病例、45 例 RE 病例和 65 例 SBE 病例中均有表达。在 SBE 病例中，2 个或更多形态变化与 HepPar1 表达相关的比例为 37%（24/65），3 个或更多特征的比例为 59%（13/22），4 个或更多特征的比例为 100%（4/4）（P≤0.004）。在没有杯状细胞的临床可疑远端食管活检病例中，某些形态变化和 HepPar1 表达的结合支持肠化生的发生。
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