自组装超分子杂双金属环的DNA结合与解旋
DNA binding and unwinding by self-assembled supramolecular hetero-bimetallacycles.
作者信息
Mishra Anurag, Ravikumar Sambandam, Hong Soon Ho, Kim Hyunuk, Vajpayee Vaishali, Lee Hyewoo, Ahn Byungchan, Wang Ming, Stang Peter J, Chi Ki-Whan
机构信息
Department of Chemistry, University of Ulsan, Ulsan 680-749, Republic of Korea.
出版信息
Organometallics. 2011 Nov 14;30(23):6343-6346. doi: 10.1021/om200802v.
Abstract
Two new tetracationic hetero-bimetallacycles were prepared from a bis-pyridine amide ligand and metal (Pd and Pt) acceptors. We found that both self-assembled hetero-bimetallacycles bind and unwind supercoiled DNA as established by photophysical and gel electrophoresis analyses, respectively.
摘要
通过双吡啶酰胺配体和金属（钯和铂）受体合成了两种新型的四价阳离子杂双金属环。我们发现，通过光物理分析和凝胶电泳分析分别证实，这两种自组装的杂双金属环均能结合并解开超螺旋DNA。
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本文引用的文献
1
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Angew Chem Int Ed Engl. 2001 Mar 2;40(5):879-884. doi: 10.1002/1521-3773(20010302)40:5<879::AID-ANIE879>3.0.CO;2-X.
2
Self-assembled molecular squares containing metal-based donor: synthesis and application in the sensing of nitro-aromatics.自组装分子方块包含基于金属的给体：在检测硝基芳烃中的应用。
Dalton Trans. 2011 Apr 7;40(13):3112-5. doi: 10.1039/c0dt01481h. Epub 2011 Feb 15.
3
Proton-mediated chemistry and catalysis in a self-assembled supramolecular host.质子介导的自组装超分子主体中的化学和催化作用。
Acc Chem Res. 2009 Oct 20;42(10):1650-9. doi: 10.1021/ar900118t.
4
Engineering discrete stacks of aromatic molecules.构建离散的芳香族分子堆叠结构。
Chem Soc Rev. 2009 Jun;38(6):1714-25. doi: 10.1039/b901261n. Epub 2009 May 6.
5
Self-organization in coordination-driven self-assembly.协调驱动自组装中的自组织。
Acc Chem Res. 2009 Oct 20;42(10):1554-63. doi: 10.1021/ar900077c.
6
Multicomponent supramolecular systems: self-organization in coordination-driven self-assembly.多组分超分子体系：配位驱动自组装中的自组织
Chemistry. 2009 Jul 20;15(29):7203-14. doi: 10.1002/chem.200900230.
7
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Inorg Chem. 2009 Jun 15;48(12):5234-43. doi: 10.1021/ic900223f.
8
Kinetically locked luminescent metallomacrocycles as duplex DNA binding substrates.动力学锁定的发光金属大环作为双链DNA结合底物。
Chem Commun (Camb). 2009 May 28(20):2947-9. doi: 10.1039/b901366k. Epub 2009 Apr 6.
9
Synthesis and characterisation of heterometallic molecular triangles using ambidentate linker: self-selection of a single linkage isomer.使用双齿连接体合成和表征异金属分子三角形：单一连接异构体的自选择。
Dalton Trans. 2009 May 7(17):3222-9. doi: 10.1039/b900118b. Epub 2009 Mar 25.
10
Metal-organic framework materials as catalysts.金属有机骨架材料作为催化剂。
Chem Soc Rev. 2009 May;38(5):1450-9. doi: 10.1039/b807080f. Epub 2009 Mar 17.
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