Mullins Michael A, Register Karen B, Bayles Darrell O, Dyer David W, Kuehn Joanna S, Phillips Gregory J
Stand Genomic Sci. 2011 Oct 15;5(1):61-8. doi: 10.4056/sigs.2245029. Epub 2011 Sep 23.
Haemophilus parasuis is a member of the family Pasteurellaceae and is the etiologic agent of Glässer's disease in pigs, a systemic syndrome associated with only a subset of isolates. The genetic basis for virulence and systemic spread of particular H. parasuis isolates is currently unknown. Strain 29755 is an invasive isolate that has long been used in the study of Glässer's disease. Accordingly, the genome sequence of strain 29755 is of considerable importance to investigators endeavoring to understand the molecular pathogenesis of H. parasuis. Here we describe the features of the 2,224,137 bp draft genome sequence of strain 29755 generated from 454-FLX pyrosequencing. These data comprise the first publicly available genome sequence for this bacterium.
副猪嗜血杆菌是巴氏杆菌科的一员,是猪格氏病的病原体,这是一种仅与部分分离株相关的全身性综合征。目前尚不清楚特定副猪嗜血杆菌分离株的毒力和全身扩散的遗传基础。29755菌株是一种侵袭性分离株,长期以来一直用于格氏病的研究。因此,29755菌株的基因组序列对于致力于了解副猪嗜血杆菌分子发病机制的研究人员具有相当重要的意义。在此,我们描述了通过454-FLX焦磷酸测序生成的29755菌株2,224,137 bp草图基因组序列的特征。这些数据是该细菌首个公开可用的基因组序列。