Kucharska J, Ulicna O, Gvozdjakova A, Vancova O, Waczulikova I, Bozek P, Bada V
Pharmacobiochemical Laboratory of Third Department of lnternal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Bratisl Lek Listy. 2011;112(11):603-4.
We focused on determination of whether atorvastatin: 1) reduces CoQ content, 2) impairs mitochondrial function and 3) induces dose-dependent changes. Although the high dose of atorvastatin exerted a beneficial effect on the lipid peroxidation in plasma, coenzyme Q content was reduced and heart mitochondrial function was impaired. Physicians should be aware when prescribing statins mainly in higher doses to the patients with co-existing proved or supposed CoQ10 deficiency resulting from age-related decline, and metabolic or mitochondrial diseases (Ref. 3).
1）降低辅酶Q含量，2）损害线粒体功能，以及3）诱导剂量依赖性变化。尽管高剂量阿托伐他汀对血浆脂质过氧化有有益作用，但辅酶Q含量降低，心脏线粒体功能受损。医生在给因年龄相关下降、代谢或线粒体疾病而存在已证实或推测的辅酶Q10缺乏的患者主要开具高剂量他汀类药物时应予以注意（参考文献3）。
