Zhao Quan-Ju, Xie Jian-Ping
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing, China.
Crit Rev Eukaryot Gene Expr. 2011;21(4):347-61. doi: 10.1615/critreveukargeneexpr.v21.i4.50.
Tuberculosis remains a global health concern. Effective novel therapeutics are urgently needed to tackle the inexorable increase of multidrug resistant and extensively drug-resistant strains and HIV coinfection. Most proteases are important for Mycobacterium tuberculosis virulence involving in the evasion or subversion of host defenses and/or tissue degradation, therefore they are ideal candidates for new drug targets. To explore this possibility, we summarize the functions of Mycobacterium tuberculosis proteases, especially their roles in pathogenesis and as inhibitors during different clinical stages.
结核病仍然是一个全球卫生问题。迫切需要有效的新型疗法来应对耐多药和广泛耐药菌株以及HIV合并感染的不断增加。大多数蛋白酶对结核分枝杆菌的毒力很重要，涉及逃避或颠覆宿主防御和/或组织降解，因此它们是新药靶点的理想候选者。为了探索这种可能性，我们总结了结核分枝杆菌蛋白酶的功能，特别是它们在发病机制中的作用以及在不同临床阶段作为抑制剂的作用。
