Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing, China.
Cell Biochem Biophys. 2013 Mar;65(2):77-83. doi: 10.1007/s12013-012-9410-x.
New antibiotic targets are urgently needed to tackle the multidrug resistant and latent Mycobacterium tuberculosis, the causative agent of the most formidable infectious disease tuberculosis. Sulfur metabolism is essential for the survival and virulence of many pathogens including M. tuberculosis. The absence of most genes involved in microbial sulfur metabolism in human beings suggests abundant novel potential antibiotic targets in pathogen sulfur metabolism. In this article, a comparative genomic landscape of Mycobacterium sulfur metabolism, such as the uptake, activation, and reduction of sulfate and allied enzymes, the biosynthesis pathway of some sulfated metabolites, and the enzymes involved in these pathways were presented. Novel clues for antibiotic targets are put forward.
急需新的抗生素靶点来应对多药耐药和潜伏的结核分枝杆菌，该菌是最具威胁性传染病结核病的病原体。硫代谢对于包括结核分枝杆菌在内的许多病原体的生存和毒力至关重要。人类缺乏大多数参与微生物硫代谢的基因，这表明病原体硫代谢中有大量潜在的新型抗生素靶点。本文介绍了分枝杆菌硫代谢的比较基因组图谱，如硫酸盐和相关酶的摄取、激活和还原、一些含硫代谢物的生物合成途径以及这些途径中涉及的酶。为抗生素靶点提出了新的线索。
