用于植入应用的17-4 PH不锈钢泡沫的生物相容性。

Biocompatibility of 17-4 PH stainless steel foam for implant applications.

作者信息

Mutlu Ilven, Oktay Enver

机构信息

Department of Metallurgical and Materials Engineering, Istanbul University, Istanbul, Turkey.

出版信息

Biomed Mater Eng. 2011;21(4):223-33. doi: 10.3233/BME-2011-0671.

DOI:10.3233/BME-2011-0671

PMID:22182790

Abstract

In this study, biocompatibility of 17-4 PH stainless steel foam for biomedical implant applications was investigated. 17-4 PH stainless steel foams having porosities in the range of 40-82% with an average pore size of around 600 μm were produced by space holder-sintering technique. Sintered foams were precipitation hardened for times of 1-6 h at temperatures between 450-570 °C. Compressive yield strength and Young's modulus of aged stainless steel foams were observed to vary between 80-130 MPa and 0.73-1.54 GPa, respectively. Pore morphology, pore size and the mechanical properties of the 17-4 PH stainless steel foams were close to cancellous bone. In vitro evaluations of cytotoxicity of the foams were investigated by XTT and MTT assays and showed sufficient biocompatibility. Surface roughness parameters of the stainless steel foams were also determined to characterize the foams.

摘要

在本研究中，对用于生物医学植入应用的17-4 PH不锈钢泡沫的生物相容性进行了研究。采用空间保持器烧结技术制备了孔隙率在40%-82%范围内、平均孔径约为600μm的17-4 PH不锈钢泡沫。烧结后的泡沫在450-570°C的温度下进行1-6小时的沉淀硬化处理。观察到时效不锈钢泡沫的抗压屈服强度和杨氏模量分别在80-130 MPa和0.73-1.54 GPa之间变化。17-4 PH不锈钢泡沫的孔隙形态、孔径和力学性能与松质骨相近。通过XTT和MTT试验对泡沫的细胞毒性进行了体外评估，结果显示其具有足够的生物相容性。还测定了不锈钢泡沫的表面粗糙度参数以表征泡沫。