小鼠对新物体的探索:并非所有物体都是一样的。
Novel object exploration in mice: not all objects are created equal.
作者信息
Heyser Charles J, Chemero Anthony
机构信息
Franklin & Marshall College, Department of Psychology, Lancaster, PA 17604, United States.
出版信息
Behav Processes. 2012 Mar;89(3):232-8. doi: 10.1016/j.beproc.2011.12.004. Epub 2011 Dec 16.
Object exploration is an increasingly popular experimental paradigm in behavioral sciences. We have begun a series of studies with mice specifically looking at the parameters that influence behaviors in this test. The aim of the present study was to examine the effect of object type on performance in the object exploration test. More specifically, adult male C57BL/6J mice were trained and tested using objects that could be climbed (CLIMB) or with those that could only be touched (TOUCH). The results show that activity is affected by the presentation of objects, with object type interacting with some of these changes. C57 mice explored objects that can be climbed over significantly longer than objects that can only be touched and a more rapid habituation was observed using objects that could only be touched. Robust recognition memory was observed in both groups of mice, however mice in the CLIMB group exhibited a significantly greater discrimination index compared to mice in the TOUCH group. Taken together, these findings demonstrate that the selection of objects is of critical importance and it is recommended that special attention be given to the functional (affordant) properties of the objects to-be-used in future studies.
物体探索是行为科学中一种越来越流行的实验范式。我们已经开始了一系列针对小鼠的研究,特别关注影响该测试中行为的参数。本研究的目的是检验物体类型对物体探索测试表现的影响。更具体地说,成年雄性C57BL/6J小鼠使用可攀爬的物体(CLIMB)或只能触摸的物体(TOUCH)进行训练和测试。结果表明,活动受到物体呈现的影响,物体类型与其中一些变化相互作用。C57小鼠探索可攀爬物体的时间明显长于只能触摸的物体,并且使用只能触摸的物体时观察到更快的习惯化。两组小鼠均观察到强大的识别记忆,然而,与TOUCH组的小鼠相比,CLIMB组的小鼠表现出明显更高的辨别指数。综上所述,这些发现表明物体的选择至关重要,建议在未来的研究中特别关注将要使用的物体的功能(可供性)特性。