大肠杆菌半乳糖操纵子中操纵基因的异常定位与功能
Unusual location and function of the operator in the Escherichia coli galactose operon.
作者信息
DiLauro R, Taniguchi T, Musso R, de Crombrugghe B
出版信息
Nature. 1979 Jun 7;279(5713):494-500. doi: 10.1038/279494a0.
DOI:10.1038/279494a0
PMID:221831
Abstract
The operator of the gal operon is located about 60 base pairs preceding the startpoints of the transcription of the two gal promoters. This location contrasts with the location of the operator in other phage or bacterial operons where the repressor binds more closely to the respective transcription initiation sites. Models explaining how the repressor-operator interactions may control the two gal promoters are presented.
摘要
半乳糖操纵子的操纵基因位于两个半乳糖启动子转录起始点之前约60个碱基对处。这一位置与其他噬菌体或细菌操纵子中操纵基因的位置形成对比，在其他操纵子中，阻遏物与各自的转录起始位点结合得更为紧密。文中提出了解释阻遏物 - 操纵基因相互作用如何控制两个半乳糖启动子的模型。
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