Bompart Marc, Haupt Karsten, Ayela Cédric
Compiègne University of Technology, UMR CNRS, 6022, 20529, 60205, Compiègne, France.
Top Curr Chem. 2012;325:83-110. doi: 10.1007/128_2011_308.
Molecularly imprinted polymers (MIPs) are tailor-made receptors that possess the most important feature of biological antibodies and receptors - specific molecular recognition. They can thus be used in applications where selective binding events are of importance, such as chemical sensors, biosensors and biochips. For the development of microsensors, sensor arrays and microchips based on molecularly imprinted polymers, micro and nanofabrication methods are of great importance since they allow the patterning and structuring of MIPs on transducer surfaces. It has been shown that because of their stability, MIPs can be easily integrated in a number of standard microfabrication processes. Thereby, the possibility of photopolymerizing MIPs is a particular advantage. In addition to specific molecular recognition properties, nanostructured MIPs and MIP nanocomposites allow for additional interesting properties in such sensing materials, for example, amplification of electromagnetic waves by metal nanoparticles, magnetic susceptibility, structural colors in photonic crystals, or others. These materials will therefore find applications in particular for chemical and biochemical detection, monitoring and screening.
分子印迹聚合物（MIPs）是定制的受体，具有生物抗体和受体最重要的特征——特异性分子识别。因此，它们可用于选择性结合事件至关重要的应用中，如化学传感器、生物传感器和生物芯片。对于基于分子印迹聚合物的微传感器、传感器阵列和微芯片的开发，微纳加工方法非常重要，因为它们能够在换能器表面对MIPs进行图案化和结构化处理。研究表明，由于其稳定性，MIPs可以很容易地集成到许多标准微加工工艺中。因此，光聚合MIPs的可能性具有特别的优势。除了特定的分子识别特性外，纳米结构的MIPs和MIP纳米复合材料在这类传感材料中还具有其他有趣的特性，例如，金属纳米颗粒对电磁波的放大、磁化率、光子晶体中的结构色等。因此，这些材料将特别适用于化学和生化检测、监测及筛选。
