Micheletti Adilha Rua, Macedo Ana Carolina Sandoval, Silva Gisele Barbosa E, Silva Ana Cristina Araújo Lemos da, Silva-Vergara Mário Leon, Murta Eddie Fernando Cândido, Adad Sheila Jorge
UFTM School of Medicine, Uberaba, MG, Brazil.
Rev Inst Med Trop Sao Paulo. 2011 Nov-Dec;53(6):309-14. doi: 10.1590/s0036-46652011000600002.
Considering that there are some studies with autopsies from AIDS describing only malignant neoplasias and that changes can occur after the introduction of Highly Active Antiretroviral Therapy (HAART), our objectives were to analyze the frequency of benign and malignant neoplasms in AIDS patients in the periods of both pre- and post-HAART. This is a retrospective study with 261 autopsies of HIV-positive patients between 1989 and 2008 in Uberaba, Brazil. Sixty-six neoplasms were found (39 benign, 21 malignant and six premalignant) in 58 patients. The most frequent malignant neoplasms were lymphoid, in 2.7% (four Non-Hodgkin lymphoma, one Hodgkin, one multiple myeloma and one plasmablastic plasmacytoma), and Kaposi's Sarcoma, in 2.3% (six cases). The most frequent benign neoplasms were hepatic hemangiomas in 11 (4.2%) of 261 cases and uterine leiomyoma in 11 (15.7%) of 70 woman. In the pre-HAART period eight (9.8%) benign neoplasias and four (4.9%) malignant occurred in 82 patients; in the post-HAART period, 29 (16.2%) benign and 17 (9.5%) malignant were present; however, the differences were not significant. We conclude that the introduction of HAART in our region doesn't look to have modified the frequency of neoplasms occurring in patients with HIV.
考虑到一些关于艾滋病尸检的研究仅描述了恶性肿瘤，并且在引入高效抗逆转录病毒疗法（HAART）后可能会发生变化，我们的目标是分析HAART治疗前后艾滋病患者良性和恶性肿瘤的发生频率。这是一项回顾性研究，对1989年至2008年期间巴西乌贝拉巴的261例HIV阳性患者进行了尸检。在58例患者中发现了66个肿瘤（39个良性，21个恶性和6个癌前病变）。最常见的恶性肿瘤是淋巴瘤，占2.7%（4例非霍奇金淋巴瘤、1例霍奇金淋巴瘤、1例多发性骨髓瘤和1例浆母细胞性浆细胞瘤），卡波西肉瘤占2.3%（6例）。最常见的良性肿瘤是肝血管瘤，在261例中有11例（4.2%），子宫平滑肌瘤在70名女性中有11例（15.7%）。在HAART治疗前，82例患者中有8例（9.8%）发生良性肿瘤，4例（4.9%）发生恶性肿瘤；在HAART治疗后，有29例（16.2%）良性肿瘤和17例（9.5%）恶性肿瘤；然而，差异不显著。我们得出结论，在我们地区引入HAART似乎并未改变HIV患者中肿瘤的发生频率。
