Stukenbrock Eva H, Dutheil Julien Y
Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Str, Marburg, Germany.
Methods Mol Biol. 2012;835:531-48. doi: 10.1007/978-1-61779-501-5_33.
Large amount of genome data are being generated by second- and now also third-generation sequencing technologies. The challenge no longer lies in the generation of the data, but in the analyses of it. We present an overview of approaches and methods to compare complete sequences of related fungal genomes. We focus on evolutionary analyses of genome alignments to describe species divergence and to identify footprints of demography and natural selection within and between species.
第二代测序技术，如今还有第三代测序技术，正在产生大量的基因组数据。挑战不再在于数据的生成，而在于对数据的分析。我们概述了用于比较相关真菌基因组完整序列的方法和途径。我们专注于基因组比对的进化分析，以描述物种分化，并识别物种内部和物种之间的种群统计学和自然选择的印记。
