Danielsson L, Stenhammar L, Aström E
Dept. of Paediatrics, Central Hospital, Danderyd, Sweden.
Scand J Gastroenterol. 1990 Sep;25(9):957-60. doi: 10.3109/00365529008997618.
Sixty-seven children under 2 years of age presenting with a classic clinical picture of coeliac disease with a severe small-intestinal mucosal lesion were investigated. All improved clinically and histologically on a gluten-free diet. During gluten challenge the mucosal damage recurred in 64 (95.5%) children, thus fulfilling the criteria for coeliac disease formulated by the European Society for Paediatric Gastroenterology and Nutrition. Three (4.5%) children had no mucosal relapse 2 years or more after return to a gluten-containing diet. These children were classified as having transient gluten intolerance. The low frequency of non-relapsers in the present study calls into question the practice of performing gluten challenge.
对67名2岁以下出现典型乳糜泻临床症状且伴有严重小肠黏膜病变的儿童进行了研究。所有儿童在采用无麸质饮食后临床症状和组织学表现均有所改善。在麸质激发试验期间，64名（95.5%）儿童再次出现黏膜损伤，从而符合欧洲儿科胃肠病学和营养学会制定的乳糜泻标准。3名（4.5%）儿童在恢复含麸质饮食2年或更长时间后未出现黏膜复发。这些儿童被归类为患有短暂性麸质不耐受。本研究中非复发者的低频率对进行麸质激发试验的做法提出了质疑。
