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前驱T细胞急性淋巴细胞白血病/淋巴瘤,膀胱罕见表现。

Precursor T-Cell acute lymphoblastic leukemia/lymphoma with rare presentation in the urinary bladder.

作者信息

Pham Alexander, Steinberg Amir, Kwok Brian, Lopez Angela, Lim Stephen, Lill Michael

机构信息

Department of Medicine and.

出版信息

Hematol Rep. 2011 Aug 31;3(2):e18. doi: 10.4081/hr.2011.e18. Epub 2011 Oct 20.

DOI:10.4081/hr.2011.e18
PMID:22184539
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3238488/
Abstract

We present the 16th reported case of Acute Lymphoblastic Leukemia (ALL) with involvement in the bladder. Our patient was a 22 year-old man with T-cell ALL with a mediastinal mass. He received hyperfractionated cyclophos-phamide, vincristine, doxorubicin, dexamethasone (HyperCVAD) with mediastinal radiation. Prior to starting maintenance, he relapsed in the bladder and marrow. He received a nelarabine-based induction regimen and achieved remission. This was followed by an unrelated 11/12 HLA-matched myeloablative allogeneic stem cell transplant. He is in complete remission for the past 409 days.

摘要

我们报告了第16例累及膀胱的急性淋巴细胞白血病(ALL)病例。我们的患者是一名22岁的男性,患有伴有纵隔肿块的T细胞ALL。他接受了超分割环磷酰胺、长春新碱、阿霉素、地塞米松(HyperCVAD)方案及纵隔放疗。在开始维持治疗之前,他在膀胱和骨髓出现复发。他接受了基于奈拉滨的诱导方案并实现缓解。随后进行了11/12 HLA配型相合的非亲缘异基因清髓性干细胞移植。在过去的409天里,他一直处于完全缓解状态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5b/3238488/71606de0a303/hr-2011-2-e18-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5b/3238488/53ba92a48b39/hr-2011-2-e18-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5b/3238488/b9ca64e8fb4e/hr-2011-2-e18-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5b/3238488/71606de0a303/hr-2011-2-e18-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5b/3238488/53ba92a48b39/hr-2011-2-e18-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5b/3238488/b9ca64e8fb4e/hr-2011-2-e18-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d5b/3238488/71606de0a303/hr-2011-2-e18-g003.jpg

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Outcome with the hyper-CVAD regimens in lymphoblastic lymphoma.淋巴细胞淋巴瘤采用高剂量环磷酰胺、长春新碱、多柔比星和地塞米松(hyper-CVAD)方案的治疗结果。
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