Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7040, USA.
Curr Opin Ophthalmol. 2012 Mar;23(2):111-7. doi: 10.1097/ICU.0b013e32834f1887.
This review highlights recently published studies on prevailing and newer laser therapies in glaucoma and critically evaluates their roles in the treatment algorithm.
Recently published studies suggest a role for selective laser trabeculoplasty (SLT) as initial therapy for open-angle glaucoma and ocular hypertension and have demonstrated efficacy in other glaucoma subtypes. Novel laser applications (micropulse diode laser trabeculoplasty, titanium sapphire laser trabeculoplasty and excimer laser trabeculotomy) have shown favorable early results. Endoscopic and transscleral cyclophotocoagulation (ECP, TCP) are generally reserved for refractory glaucomas, although some recent studies report its use in patients with good visual acuity. The effectiveness of laser iridotomy with or without iridoplasty for long-term prevention of primary angle closure glaucoma is undetermined. Laser goniopuncture is an important adjunct to nonpenetrating surgery, but wide adoption of the procedure is lacking.
The use of lasers in glaucoma continues to evolve, with a trend towards primary and earlier intervention. SLT is assuming an expanded role in the treatment of additional subtypes of glaucoma, whereas ECP and TCP are generally reserved for refractory glaucomas. Newer laser modalities show promise as alternatives and adjuncts to topical medications and nonpenetrating surgery. Additional research is needed to better define their safety and efficacy.
本文重点介绍了最近发表的关于青光眼现有和新型激光治疗的研究,并对其在治疗方案中的作用进行了批判性评估。
最近发表的研究表明,选择性激光小梁成形术(SLT)可作为开角型青光眼和高眼压症的初始治疗方法,并且在其他青光眼亚型中也显示出疗效。新型激光应用(微脉冲二极管激光小梁成形术、钛宝石激光小梁成形术和准分子激光小梁切开术)显示出良好的早期效果。尽管一些最新的研究报告称其可用于视力良好的患者,但经内镜和经巩膜睫状体光凝术(ECP、TCP)通常仅保留用于难治性青光眼。激光虹膜切开术联合或不联合虹膜成形术是否能长期预防原发性闭角型青光眼尚不确定。激光房角穿刺术是一种重要的非穿透性手术辅助手段,但该手术的广泛应用仍有待进一步研究。
激光在青光眼治疗中的应用不断发展,呈现出早期和初始干预的趋势。SLT 在治疗其他类型青光眼方面的作用不断扩大,而 ECP 和 TCP 通常仅保留用于难治性青光眼。新型激光治疗模式作为局部药物和非穿透性手术的替代和辅助手段显示出良好的应用前景。需要进一步的研究来更好地确定其安全性和疗效。