Department of Craniofacial Development, GKT Dental Institute, King's College, Guy's Hospital, London Bridge, London SE1 9RT, UK.
Arch Oral Biol. 2012 Jun;57(6):805-13. doi: 10.1016/j.archoralbio.2011.11.014. Epub 2011 Dec 18.
Tongue papillae are critical organs in mastication. There are four different types of tongue papillae; fungiform, circumvallate, foliate, and filiform papillae. Unlike the other three taste papillae, non-gustatory papillae, filiform papillae cover the entire dorsal surface of the tongue and are important structures for the mechanical stress of sucking. Filiform papillae are further classified into two subtypes with different morphologies, depending on their location on the dorsum of the tongue. The filiform papillae at the intermolar eminence have pointed tips, whereas filiform papillae with rounded tips are found in other regions (anterior tongue). It remains unknown how the shape of each type of filiform papillae are determined during their development. Bmp signalling pathway has been known to regulate mechanisms that determine the shapes of many ectodermal organs. The aim of this study was to investigate the role of Bmp signalling in filiform papillae development.
Comparative in situ hybridization analysis of six Bmps (Bmp2-Bmp7) and two Bmpr genes (Bmpr1a and Bmpr1b) were carried out in filiform papillae development. We further examined tongue papillae in mice over-expressing Noggin under the keratin14 promoter (K14-Noggin).
We identified a dynamic temporo-spatial expression of Bmps in filiform papillae development. The K14-Noggin mice showed pointed filiform papillae in regions of the tongue normally occupied by the rounded type.
Bmp signalling thus regulates the shape of filiform papillae.
舌乳头是咀嚼的关键器官。舌乳头有四种不同类型：菌状乳头、轮廓乳头、叶状乳头和丝状乳头。与其他三种味觉乳头（非味觉乳头）不同，丝状乳头覆盖舌背的整个表面，是吸吮机械力的重要结构。丝状乳头根据其在舌背的位置进一步分为两种不同形态的亚型。位于磨牙后嵴的丝状乳头尖端呈尖形，而在其他区域（舌尖）发现的尖端呈圆形的丝状乳头。目前尚不清楚每种丝状乳头在发育过程中的形状是如何确定的。Bmp 信号通路已被证明可以调节许多外胚层器官形状的决定机制。本研究旨在探讨 Bmp 信号在丝状乳头发育中的作用。
对丝状乳头发育过程中的六种 Bmp（Bmp2-Bmp7）和两种 Bmpr 基因（Bmpr1a 和 Bmpr1b）进行了比较原位杂交分析。我们进一步检查了在角蛋白 14 启动子（K14-Noggin）下过表达 Noggin 的小鼠的舌乳头。
我们在丝状乳头发育过程中鉴定了 Bmp 的动态时空表达。K14-Noggin 小鼠在正常由圆形类型占据的舌区域显示出尖锐的丝状乳头。
Bmp 信号因此调节丝状乳头的形状。
