Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Br J Cancer. 2012 Jan 17;106(2):243-7. doi: 10.1038/bjc.2011.551. Epub 2011 Dec 20.
Accumulated evidence shows that EZH2 is deregulated in a wide range of cancer types, and it has a crucial role in stem cell maintenance and tumour development. Therefore, blocking EZH2 expression or activity may represent a promising strategy for anticancer treatment. In this review, we address the current understanding of the mechanisms underlying EZH2 regulation alongside the function of EZH2 gene targets that are involved in cancer progression. Finally, we will describe cancer therapies that target EZH2 or its downstream cascades, which could potentially reverse the oncogenic and stemness properties of the tumour cells to suppress cancer progression and recurrence.
积累的证据表明，EZH2 在广泛的癌症类型中失调，并且在干细胞维持和肿瘤发展中起着关键作用。因此，阻断 EZH2 的表达或活性可能代表着一种有前途的抗癌治疗策略。在这篇综述中，我们讨论了 EZH2 调节的机制以及 EZH2 基因靶点在癌症进展中的功能的最新认识。最后，我们将描述针对 EZH2 或其下游级联的癌症治疗方法，这些方法可能逆转肿瘤细胞的致癌和干性特性，从而抑制癌症的进展和复发。
