Department of Paediatric Haematology, Royal Belfast Hospital for Sick Children, Belfast, Northern Ireland, United Kingdom.
Semin Thromb Hemost. 2011 Oct;37(7):763-1. doi: 10.1055/s-0031-1297167. Epub 2011 Dec 20.
Thrombosis in children is becoming more prevalent due to increased awareness of these issues in the pediatric population and advances in medicine. Management of affected children are challenging due to differences in their hemostatic system compared with adults. Prospective, controlled trials for management/treatment of children with thrombosis are lacking. Many of the available guidelines for treatment of thrombosis in children are extrapolated from adult data and do not account for the uniqueness of the pediatric hemostatic system, although more research and data are becoming available. This review will focus on children over 1 year of age, including adolescents, looking at the etiology of thrombosis, diagnosis, management options, and any associated complications in this pediatric population.
由于儿科人群对这些问题的认识提高以及医学的进步,儿童中的血栓形成变得更为普遍。由于儿童的止血系统与成人不同,因此管理受影响的儿童具有挑战性。缺乏针对患有血栓形成的儿童进行管理/治疗的前瞻性、对照试验。许多现有的儿童血栓形成治疗指南都是从成人数据推断而来,并未考虑儿科止血系统的独特性,尽管正在获得更多的研究和数据。这篇综述将重点关注 1 岁以上的儿童,包括青少年,探讨血栓形成的病因、诊断、治疗选择以及该儿科人群中的任何相关并发症。