Basu Anjana, Saha Debdas, Hembrom Bani P, Roy Amit, Naaz Anjum
Department of Anaesthesiology, RG Kar Medical College, Kolkata.
J Indian Med Assoc. 2011 May;109(5):327-9.
The objective of the study was to compare the efficacy of palanosetron (0.25 mg), granisetron (3.0 mg) and ondansetron (8.0 mg) used as anti-emetics for the prevention of postoperative nausea/vomiting in patients undergoing middle ear surgery. The study was done among 75 adult patients (age group 30-45 years) of which 50 were males and rest (25) females, all of ASA I and ASA II. The patients were randomly allocated into 3 equal groups: Group I (n = 25) received injection palanosetron (0.25 mg) IV, group II (n = 25) received injection granisetron (3 mg) IV and group III (n = 25) received injection ondansetron (8.0 mg) IV at the end of the surgical procedure. A standard general anaesthesia technique was employed. Emetic episodes and safety assessments were performed during two periods of 0-6 hours in the postanaesthesia care unit and 6-24 hours in the ward after anaesthesia. The incidence of emesis-free patients during the 0-6 hours period was 100% for group I; 72% for group II and 56% for group III. During the 6-24 hours period incidence of emesis-free patients were 96% for group I; 56% for group II and 32% for group III. So to conclude, a single dose of palanosetron (0.25 mg) is a superior anti-emetic to granisetron (3.0 mg) or ondansetron (8.0 mg) in complete prevention of postoperative nausea and vomiting after middle ear surgery during the first 24 hours period.
本研究的目的是比较帕洛诺司琼（0.25毫克）、格拉司琼（3.0毫克）和昂丹司琼（8.0毫克）作为止吐药预防中耳手术患者术后恶心/呕吐的疗效。该研究在75名成年患者（年龄30 - 45岁）中进行，其中50名男性，其余25名女性，均为ASA I级和ASA II级。患者被随机分为3组，每组25人：第一组（n = 25）在手术结束时静脉注射帕洛诺司琼（0.25毫克）；第二组（n = 25）静脉注射格拉司琼（3毫克）；第三组（n = 25）静脉注射昂丹司琼（8.0毫克）。采用标准的全身麻醉技术。在麻醉后护理单元的0 - 6小时和麻醉后病房的6 - 24小时两个时间段进行呕吐发作情况和安全性评估。在0 - 6小时期间，第一组无呕吐患者的发生率为100%；第二组为72%，第三组为56%。在6 - 24小时期间，第一组无呕吐患者的发生率为96%；第二组为56%，第三组为32%。因此可以得出结论，在完全预防中耳手术后24小时内的术后恶心和呕吐方面，单剂量的帕洛诺司琼（0.25毫克）作为止吐药优于格拉司琼（3.0毫克）或昂丹司琼（8.0毫克）。
