Ray Somosri, Mukherjee Asha, Chatterjee Nandita, Alam Mirza Asraful
Department of Paediatrics, VIMS (RKMSP), Kolkata 700026.
J Indian Med Assoc. 2011 May;109(5):354-5.
Neonatal cutaneous mastocytosis is rare infiltrative disorder of the skin. Though often asymptomatic, systemic features may be associated with any clinical pattern of the disorder at any age group. We present our experience with a 3 1/2 months old female child. She presented with recurrent eruption of tense bullae preceded by flushing, irritability since day 3 of life. Darier sign and dermatographism were present. Skin biopsy confirmed the case as urticaria pigmentosa which is the most common form of cutaneous mastocytosis. Investigation revealed deranged liver function. Child was given H1 antihistaminics and topical glucocorticoid. Family counselled about chance of anaphylaxis to various toxins and drugs and risk of development of systemic mastocytosis.
新生儿皮肤肥大细胞增多症是一种罕见的皮肤浸润性疾病。尽管通常无症状，但在任何年龄组，全身特征可能与该疾病的任何临床类型相关。我们介绍我们对一名3个半月大女童的诊治经验。她自出生第3天起就出现反复出现的紧张性大疱疹，之前有潮红、易激惹症状。存在 Darier 征和皮肤划痕症。皮肤活检确诊为色素性荨麻疹，这是皮肤肥大细胞增多症最常见的形式。检查发现肝功能紊乱。患儿接受了 H1 抗组胺药和外用糖皮质激素治疗。已向患儿家属告知对各种毒素和药物发生过敏反应的可能性以及发生系统性肥大细胞增多症的风险。
