Flinders Medical Centre, Bedford Park, SA, Australia.
J Thromb Haemost. 2012 Feb;10(2):229-35. doi: 10.1111/j.1538-7836.2011.04598.x.
Patients undergoing neurosurgical procedures are at risk of venous thromboembolism (VTE), but often have contraindications for anticoagulant prophylaxis.
To assess the efficacy and tolerability of a new, lightweight, portable, battery-powered, intermittent calf compression device, Venowave, for the prevention of VTE in neurosurgical inpatients.
PATIENTS/METHODS: We performed an open randomized controlled trial comparing Venowave with control for the prevention of VTE in patients undergoing neurosurgery. The primary outcome was the composite of asymptomatic deep vein thrombosis (DVT) detected by screening venography or compression ultrasound performed on day 9 (± 2 days) and symptomatic VTE.
We randomized 75 patients to receive Venowave devices and 75 to the control group. All patients were prescribed graduated compression stockings and physiotherapy. VTE occurred in three patients randomized to Venowave and in 14 patients randomized to control (4.0% vs. 18.7%, relative risk 0.21; 95% confidence interval 0.05-0.75, P = 0.008). Similar reductions were seen for proximal DVT (2.7% vs. 8.0%) and symptomatic VTE (0% vs. 2.7%), and the results were consistent in all subgroups examined.
Venowave devices are effective in preventing VTE in high-risk neurosurgical patients.
接受神经外科手术的患者存在静脉血栓栓塞（VTE）的风险，但通常存在抗凝预防的禁忌证。
评估新型轻便、便携式、电池供电、间歇性小腿压缩装置 Venowave 在预防神经外科住院患者 VTE 中的疗效和耐受性。
患者/方法：我们进行了一项开放随机对照试验，比较了 Venowave 与对照组预防神经外科手术患者 VTE 的效果。主要结局是第 9 天（±2 天）通过筛选性静脉造影或压缩超声检测到的无症状深静脉血栓形成（DVT）和症状性 VTE 的复合结果。
我们将 75 例患者随机分配至 Venowave 组和对照组。所有患者均被开具梯度压缩袜和物理治疗处方。Venowave 组有 3 例患者发生 VTE，对照组有 14 例（4.0%比 18.7%，相对风险 0.21；95%置信区间 0.05-0.75，P=0.008）。近端 DVT（2.7%比 8.0%）和症状性 VTE（0%比 2.7%）也出现类似的降低，所有检查的亚组结果均一致。
Venowave 装置在预防高危神经外科患者 VTE 方面有效。
