Texas Fertility Center and Austin IVF, Austin, Texas.
Fertil Steril. 2012 Feb;97(2):344-8. doi: 10.1016/j.fertnstert.2011.11.018. Epub 2011 Dec 19.
To compare the efficacy of intravaginal and IMP for luteal phase support in IVF cycles.
Prospective trial.
Tertiary care private practice.
PATIENT(S): Women 25-44 years old with infertility necessitating treatment with IVF. From April 1, 2008-April 1, 2009, 511 consecutive patients were enrolled; 474 completed participation, and 37 were excluded for no autologous ET (freeze all, donor recipients, failed fertilization/cleavage). There were no demographic differences between the two treatment groups.
INTERVENTION(S): Luteal phase support using either Crinone or P in oil starting 2 days following oocyte retrieval.
MAIN OUTCOME MEASURE(S): Pregnancy and delivery rates stratified by patient age.
RESULT(S): Overall, patients who received vaginal P had higher pregnancy (70.9% vs. 64.2%) and delivery (51.7% vs. 45.4%) rates than did patients who received IMP. Patients <35 who received vaginal P had significantly higher delivery rates (65.7% vs. 51.1%) than did patients who received IMP. There were no differences, regardless of age, in the rates of biochemical pregnancy, miscarriage, or ectopics.
CONCLUSION(S): In younger patients undergoing IVF, support of the luteal phase with Crinone produces significantly higher pregnancy rates than does IMP. Crinone and IMP appear to be equally efficacious in the older patient.
比较阴道内和肌内孕酮（IMP）在体外受精（IVF）周期中黄体期支持的疗效。
前瞻性试验。
三级保健私人诊所。
年龄在 25-44 岁之间，因不孕需要接受 IVF 治疗的女性。2008 年 4 月 1 日至 2009 年 4 月 1 日，共纳入 511 例连续患者；474 例完成了参与，37 例因无自体 ET（全部冷冻、供体受者、受精/卵裂失败）而被排除。两组治疗患者之间无人口统计学差异。
在取卵后 2 天开始，使用普罗雌烯或 P 在油中进行黄体期支持。
按患者年龄分层的妊娠和分娩率。
总体而言，接受阴道 P 治疗的患者妊娠（70.9% vs. 64.2%）和分娩（51.7% vs. 45.4%）率高于接受 IMP 治疗的患者。接受阴道 P 的<35 岁患者的分娩率（65.7% vs. 51.1%）显著高于接受 IMP 的患者。无论年龄大小，生化妊娠、流产或宫外孕的发生率均无差异。
在接受 IVF 的年轻患者中，普罗雌烯支持黄体期可显著提高妊娠率，优于 IMP。普罗雌烯和 IMP 在老年患者中的疗效似乎相当。
