Diadyk A I, Vasilenko I V, Bagriĭ A E, Chernykh O S, Iarovaia N F, Shpilevaia N I, Khomenko M V, Kobets V G
Ter Arkh. 1990;62(6):34-7.
The author relates the data on the time-course of changes in diurnal proteinuria, diastolic arterial pressure and blood creatinine in 123 patients with primary chronic glomerulonephritis seen during 159 pregnancies. The dependence of the character of those changes on the respective parameters before conception was analyzed as was such a dependence, in part of the patients, on the morphological disease pattern. The rise of proteinuria and diastolic arterial pressure during gestation was seen more often in women with initial diurnal protein losses exceeding 1g and with arterial hypertension that occurred before pregnancy. The rise of blood creatinine before conception was a prognostically unfavourable sign. Mesangiocapillary glomerulonephritis occurring in the gestation period is viewed as less favourable as compared to mesangioproliferative glomerulonephritis.
作者阐述了123例原发性慢性肾小球肾炎患者在159次妊娠期间昼夜蛋白尿、舒张压和血肌酐变化的时间进程数据。分析了这些变化特征与受孕前各自参数的相关性，部分患者还分析了其与形态学疾病模式的相关性。妊娠期间蛋白尿和舒张压升高在初始昼夜蛋白丢失超过1g且孕前发生动脉高血压的女性中更为常见。受孕前血肌酐升高是预后不良的迹象。与系膜增生性肾小球肾炎相比，妊娠期发生的系膜毛细血管性肾小球肾炎被认为预后较差。
