Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Neurology. 2012 Jan 24;78(4):232-40. doi: 10.1212/WNL.0b013e31824365ab. Epub 2011 Dec 21.
To determine the relationship between β-amyloid (Aβ) load as measured by [(11)C]-Pittsburgh compound B (PiB) PET and cognitive function in cognitively normal older adults.
We studied 408 cognitively normal older adults who participated in the population-based Mayo Clinic Study of Aging (MCSA) from January 2009 through March 2011. The participants underwent PiB PET and neuropsychometric testing within 6 months. The association between PiB retention and cognitive function was measured by partial correlation and an interaction with APOE status was tested using linear regression after adjusting for age, sex, and education.
Higher PiB retention was associated with cognitive performance (Spearman partial r = -0.18; p < 0.01), specifically the memory, language, attention/executive, and visual-spatial processing domains in the whole group of participants. The association between PiB retention and cognition was modified by the APOE status on linear regression analysis even after controlling for the differences in the distribution of PiB values among APOE ε4 carriers and noncarriers (p = 0.02). Cognitive performance was associated with the Aβ deposition in the frontal, temporal, and parietal lobe association cortices in APOE ε4 carriers on SPM analysis (p < 0.001).
There is a modest association between PiB retention and cognitive function in cognitively normal older adults and this relationship between Aβ load and cognitive function is modified by APOE status. Whereas Aβ load is associated with greater cognitive impairment in APOE ε4 carriers, the cognitive function in APOE ε4 noncarriers is influenced less by the Aβ load, suggesting that APOE isoforms modulate the harmful effects of Aβ on cognitive function.
确定[(11)C]-匹兹堡化合物 B（PiB）正电子发射断层扫描（PET）测量的β-淀粉样蛋白（Aβ）负荷与认知功能正常的老年人认知功能之间的关系。
我们研究了 408 名认知功能正常的老年人，他们于 2009 年 1 月至 2011 年 3 月参加了基于人群的梅奥诊所衰老研究（MCSA）。参与者在 6 个月内接受 PiB PET 和神经心理测试。在用年龄、性别和教育进行调整后，使用线性回归测试 PiB 保留与认知功能之间的关联，并用偏相关测量，并测试 APOE 状态的交互作用。
较高的 PiB 保留与认知表现相关（Spearman 偏相关 r = -0.18；p < 0.01），特别是在整个参与者组中记忆、语言、注意力/执行和视觉空间处理领域。即使在控制 APOE ε4 携带者和非携带者之间 PiB 值分布差异后，线性回归分析也表明 PiB 保留与认知之间的关联发生了变化（p = 0.02）。SPM 分析表明，APOE ε4 携带者的额叶、颞叶和顶叶联合皮质的 Aβ 沉积与认知表现相关（p < 0.001）。
在认知功能正常的老年人中，PiB 保留与认知功能之间存在适度的关联，而这种 Aβ 负荷与认知功能之间的关系受到 APOE 状态的调节。虽然 Aβ 负荷与 APOE ε4 携带者的认知障碍程度相关更大，但 APOE ε4 非携带者的认知功能受 Aβ 负荷的影响较小，这表明 APOE 同工型调节 Aβ 对认知功能的有害影响。
