Institute of Myology, NMR Laboratory, Paris, France.
Magn Reson Med. 2012 May;67(5):1379-90. doi: 10.1002/mrm.23131. Epub 2011 Aug 16.
A fast and robust methodology for in vivo T(2) mapping is presented. The approach is based on the partially spoiled steady state free precession technique recently proposed by Bieri et al. (Magn Reson Med 2011). The accuracy of this method was demonstrated in simulations and phantom experiments. Variations in skeletal muscle T(2) relaxation time have been correlated with cell damage and inflammatory response. Nonetheless, the lack of easily implementable, fast, accurate and reproducible methods has hampered the adoption of T(2) measurement as a noninvasive tool for skeletal muscle characterization. The applicability of the partially spoiled steady state free precession method for tissue characterization in muscle disease is illustrated in this work by several examples. Quantitative MRI, in particular T(2) mapping based on partially spoiled steady state free precession acquisitions, might provide objective markers of muscle damage and degenerative changes, and an alternative to serial muscle biopsies.
提出了一种快速、稳健的活体 T(2) 映射方法。该方法基于 Bieri 等人最近提出的部分饱和稳态自由进动技术（Magn Reson Med 2011）。该方法的准确性已在模拟和体模实验中得到验证。骨骼肌 T(2)弛豫时间的变化与细胞损伤和炎症反应有关。尽管如此，由于缺乏易于实现、快速、准确和可重复的方法，T(2)测量作为一种无创工具用于骨骼肌特征描述的应用受到了阻碍。本工作通过多个实例说明了部分饱和稳态自由进动方法在肌肉疾病组织特征描述中的适用性。定量 MRI，特别是基于部分饱和稳态自由进动采集的 T(2)映射，可能为肌肉损伤和退行性变化提供客观标志物，并替代连续肌肉活检。
