Piraccini B, Starace M, Alessandrini A, Guarrera M, Fiorucci M C, Lorenzi S
Department of Internal Medicine, University of Bologna, Bologna, Italy.
G Ital Dermatol Venereol. 2011 Dec;146(6 Suppl 1):1-8.
The aim of the study was to evaluate efficacy and safety of 5% Carexidil solution®, applied twice a day on the scalp, on male and female androgenetic alopecia.
The 6 month-study was performed in three Italian dermatological centers. Evaluation of efficacy was performed with subjective and objective methods, including operator and patient assessments, global photography and videodermoscopy.
Global photography revealed that after 6 months of treatment with 5% Carexidil solution®, androgenetic alopecia was improved in all 32 females and 16 males. Alopecia stopped to progress in 6 males. Scalp videodermoscopy confirmed the results. Some patients complained of increased hair greasiness, others complained of mild scalp itching. Two female patients developed contact sensitization to minoxidil, confirmed by patch test, 2 a mild malar-temporal hypertrichosis. All patients were satisfied by treatment and continued it after the end of the study.
Our study confirms the data of the literature and the evidence coming from years of clinical experience, that twice a day topical application of 5% minoxidil solution, Carexidil ®, is effective in the treatment of male and female androgenetic alopecia, with evident efficacy already after 6 months.
本研究旨在评估每天两次将5%卡雷西地尔溶液（Carexidil solution®）涂抹于头皮上治疗男性和女性雄激素性脱发的疗效和安全性。
这项为期6个月的研究在三个意大利皮肤病中心进行。采用主观和客观方法评估疗效，包括医生和患者评估、整体摄影和皮肤镜检查。
整体摄影显示，使用5%卡雷西地尔溶液治疗6个月后，32名女性和16名男性的雄激素性脱发均有所改善。6名男性的脱发停止进展。头皮皮肤镜检查证实了这一结果。一些患者抱怨头发油腻感增加，另一些患者抱怨头皮轻度瘙痒。两名女性患者经斑贴试验证实对米诺地尔发生接触性致敏，两名出现轻度颞部黄褐斑。所有患者对治疗均满意，并在研究结束后继续治疗。
我们的研究证实了文献数据以及多年临床经验的证据，即每天两次局部应用5%米诺地尔溶液（卡雷西地尔®）对治疗男性和女性雄激素性脱发有效，6个月后即有明显疗效。
