Blume-Peytavi Ulrike, Kunte Christian, Krisp Andreas, Garcia Bartels Natalie, Ellwanger Ulf, Hoffmann Rolf
Department of Dermatology and Allergy, Charité- Medical University, Berlin, Germany.
J Dtsch Dermatol Ges. 2007 May;5(5):391-5. doi: 10.1111/j.1610-0387.2007.06295.x.
Two drugs which are approved for the treatment of androgenetic alopecia in women in Germany were compared with regard to their influence on hair growth.
Patients were randomized to group I (n = 52) who used 2% minoxidil solution twice daily for a period of 12 months or to group II (n = 51) who used 0.025% alfatradiol solution once daily for 6 months and were then switched to 2% minoxidil solution for months 7-12. Changes in hair growth parameters were determined using the TrichoScan.
Topical treatment with 2% minoxidil solution for 6 months resulted in a significant increase of cumulative hair thickness (p < 0.0001) and absolute hair density (p < or = 0.0025), whereas these parameters of hair growth remained nearly unchanged after 6 months of treatment with alfatradiol solution. Evaluation of the same parameters from month 7 to month 12 demonstrated that 12 months minoxidil treatment resulted in an increasing stabilization (group I). After the alfatradiol-->minoxidil switch in group II a significant increase in cumulative hair thickness (p < 0.0001) and absolute hair density (p < 0.0001) was achieved. Both study medications were well tolerated.
Treatment with minoxidil can induce an increase in hair density and hair thickness,whereas treatment with alfatradiol results in deceleration or stabilization of hair loss.
比较了德国两种已获批用于治疗女性雄激素性脱发的药物对头发生长的影响。
将患者随机分为两组，第一组（n = 52）每天使用两次2%米诺地尔溶液，持续12个月；第二组（n = 51）每天使用一次0.025%阿法骨化醇溶液，持续6个月，然后在第7至12个月改用2%米诺地尔溶液。使用毛发扫描仪（TrichoScan）测定头发生长参数的变化。
外用2%米诺地尔溶液治疗6个月后，累积毛发厚度显著增加（p < 0.0001），绝对毛发密度增加（p ≤ 0.0025），而使用阿法骨化醇溶液治疗6个月后，这些头发生长参数几乎没有变化。对第7至12个月相同参数的评估表明，米诺地尔治疗12个月后效果逐渐稳定（第一组）。在第二组中，从阿法骨化醇改用米诺地尔后，累积毛发厚度（p < 0.0001）和绝对毛发密度（p < 0.0001）显著增加。两种研究药物耐受性良好。
米诺地尔治疗可增加毛发密度和厚度，而阿法骨化醇治疗可减缓或稳定脱发。
