Storm-Mathisen I, Glomstein A, Lie S O, Albrechtsen D, Monclair T, Kvalheim G, Jacobsen A B
Barneklinikken, Rikshospitalet, Oslo.
Tidsskr Nor Laegeforen. 1990 Aug 20;110(19):2513-6.
Autologous bone marrow transplantation permits the use of greatly intensified cytoreductive therapy for cancer. Since 1983 seven children with disseminated neuroblastoma (stage IV) were treated by this method. Five were treated in first, and one in second complete remission; one child was in partial remission. Tumor cell purging of the marrow inoculum was performed in five cases. All children had engraftment and were discharged from hospital free of disease. Relapse was observed in three children within two years. Four children remain healthy at follow-up 5-77 months after autotransplantation. We describe and discuss indications, methods, side effects and results.
自体骨髓移植允许对癌症使用强度更大的细胞减灭疗法。自1983年以来，7例播散性神经母细胞瘤（IV期）患儿接受了这种治疗方法。5例在首次完全缓解期接受治疗，1例在第二次完全缓解期接受治疗；1例患儿为部分缓解。5例对骨髓接种物进行了肿瘤细胞清除。所有患儿均实现植入，且无疾病出院。3例患儿在两年内出现复发。4例患儿在自体移植后5 - 77个月的随访中保持健康。我们描述并讨论了适应证、方法、副作用及结果。
