de Kraker J, Boon F, van Leeuwen E F, Voûte P A
Emma Kinderziekenhuis/het Kinder-AMC, afd. Kinderoncologie, Amsterdam.
Ned Tijdschr Geneeskd. 1994 Oct 15;138(42):2097-100.
To evaluate the role of high dose chemotherapy and autologous bone marrow transplantation (ABMT) in children with metastasized neuroblastoma (stage IV) in partial or complete remission.
Retrospective analysis.
The former Emma Child Hospital and the Academic Medical Center, Amsterdam.
In the period January 1980 to May 1991, ABMT was used in 30 children (mean age 3 years) with a neuroblastoma stage IV treated with chemotherapy. Occurrence of fever, infections, haemorrhagic diathesis, mucositis, ileus and the duration of hospital stay were measured as indications of illness. The mean weight loss and the duration of aplasia were also measured.
Eight of 30 patients stayed alive until June 1993. Three patients died within 1 month after start of treatment. The median survival of the other 19 patients was 15 months. The mean weight loss was 7.6% and the period of aplasia had a mean duration of 18-20 days. Two-year disease free survival was 26.6% with a median follow-up of 118.5 months (29-150).
评估大剂量化疗及自体骨髓移植（ABMT）在部分或完全缓解的转移性神经母细胞瘤（IV期）患儿中的作用。
回顾性分析。
原艾玛儿童医院及阿姆斯特丹学术医疗中心。
在1980年1月至1991年5月期间，30名（平均年龄3岁）接受化疗的IV期神经母细胞瘤患儿接受了ABMT。测量发热、感染、出血素质、粘膜炎、肠梗阻的发生情况及住院时间作为疾病指标。还测量了平均体重减轻及再生障碍期的持续时间。
30名患者中有8名存活至1993年6月。3名患者在治疗开始后1个月内死亡。其他19名患者的中位生存期为15个月。平均体重减轻7.6%，再生障碍期平均持续18 - 20天。两年无病生存率为26.6%，中位随访时间为118.5个月（29 - 150个月）。
