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Perspective: The clinical trial barriers.

作者信息

Liu Liang, Leung Elaine Lai-Han, Tian Xiaoying

机构信息

State Key Laboratory for Quality Research in Chinese Medicines, Macau University of Science and Technology, China.

出版信息

Nature. 2011 Dec 21;480(7378):S100. doi: 10.1038/480S100a.

DOI:10.1038/480S100a
PMID:22190082
Abstract
摘要

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Traditional Chinese medicine for cardiovascular disease: efficacy and safety.用于心血管疾病的传统中药：疗效与安全性。
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Predicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial.雷公藤多苷治疗类风湿关节炎疗效的预测与验证：从开放试验到双盲随机试验
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本文引用的文献

1
Systems biology-based diagnostic principles as pillars of the bridge between Chinese and Western medicine.基于系统生物学的诊断原则是中西医结合的桥梁。
Planta Med. 2010 Dec;76(17):2036-47. doi: 10.1055/s-0030-1250450. Epub 2010 Oct 26.
2
From genomic landscapes to personalized cancer management-is there a roadmap?从基因组景观到个体化癌症管理——是否存在路线图？
Ann N Y Acad Sci. 2010 Oct;1210:34-44. doi: 10.1111/j.1749-6632.2010.05776.x.
3
Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: data from the randomized phase III INTEREST trial.
通过甲硫氨酸790氧化诱导表皮生长因子受体降解来靶向治疗酪氨酸激酶抑制剂耐药的非小细胞肺癌
Antioxid Redox Signal. 2016 Feb 10;24(5):263-79. doi: 10.1089/ars.2015.6420. Epub 2015 Dec 14.
4
Mutation of cysteine 46 in IKK-beta increases inflammatory responses.IKK-β中半胱氨酸46的突变会增加炎症反应。
Oncotarget. 2015 Oct 13;6(31):31805-19. doi: 10.18632/oncotarget.5567.
5
What has been overlooked on study of Chinese materia medica in the West?西方对中药的研究忽略了什么？
Chin J Integr Med. 2015 Jul;21(7):483-92. doi: 10.1007/s11655-015-2081-x. Epub 2015 Jul 9.
6
Wrist-ankle acupuncture for the treatment of pain symptoms: a systematic review and meta-analysis.腕踝针治疗疼痛症状：系统评价和荟萃分析。
Evid Based Complement Alternat Med. 2014;2014:261709. doi: 10.1155/2014/261709. Epub 2014 Jul 15.
7
Building an Evidence-Base for TCM and Integrative East-West Medicine: A Review of Recent Developments in Innovative Research Design.构建中医和中西医结合的证据基础：创新性研究设计的最新进展综述。
J Tradit Complement Med. 2012 Jul;2(3):158-63. doi: 10.1016/s2225-4110(16)30095-5.
8
Traditional chinese medicine syndromes for essential hypertension: a literature analysis of 13,272 patients.高血压病中医证候文献分析 13272 例
Evid Based Complement Alternat Med. 2014;2014:418206. doi: 10.1155/2014/418206. Epub 2014 Feb 10.
9
Trends in the treatment of hypertension from the perspective of traditional chinese medicine.从中医角度看高血压治疗趋势。
Evid Based Complement Alternat Med. 2013;2013:275279. doi: 10.1155/2013/275279. Epub 2013 Jun 26.
10
Chinese herbal medicine qi ju di huang wan for the treatment of essential hypertension: a systematic review of randomized controlled trials.中药杞菊地黄丸治疗原发性高血压的系统评价：随机对照试验研究。
Evid Based Complement Alternat Med. 2013;2013:262685. doi: 10.1155/2013/262685. Epub 2013 Jun 25.
吉非替尼和多西他赛治疗既往治疗的非小细胞肺癌的分子预后因素：来自随机 III 期 INTEREST 试验的数据。
J Clin Oncol. 2010 Feb 10;28(5):744-52. doi: 10.1200/JCO.2009.24.3030. Epub 2009 Dec 28.
4
Systems biology guided by Chinese medicine reveals new markers for sub-typing rheumatoid arthritis patients.系统生物学指导下的中医揭示了类风湿关节炎患者亚分型的新标志物。
J Clin Rheumatol. 2009 Oct;15(7):330-7. doi: 10.1097/RHU.0b013e3181ba3926.
5
Back to the future: why randomized controlled trials cannot be the answer to pharmacogenomics and personalized medicine.回到未来：为什么随机对照试验不能成为药物基因组学和个性化医学的答案。
Pharmacogenomics. 2009 Jul;10(7):1077-81. doi: 10.2217/pgs.09.62.
6
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.肺癌中的表皮生长因子受体（EGFR）突变：与吉非替尼治疗临床反应的相关性
Science. 2004 Jun 4;304(5676):1497-500. doi: 10.1126/science.1099314. Epub 2004 Apr 29.
7
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.表皮生长因子受体中的激活突变是非小细胞肺癌对吉非替尼产生反应的基础。
N Engl J Med. 2004 May 20;350(21):2129-39. doi: 10.1056/NEJMoa040938. Epub 2004 Apr 29.