Department of Neurology, Washington University, St. Louis, MO 63110, USA.
Sci Transl Med. 2011 Dec 21;3(114):114ps48. doi: 10.1126/scitranslmed.3003529.
Alzheimer's disease (AD) is the most common cause of dementia and will lead to a worldwide public health crisis if it continues unchecked. Despite tremendous advances in our scientific understanding of AD, we still do not have effective ways to delay, prevent, or slow this disease. At the 2011 Abelson meeting, a diverse group of scientists discussed current challenges in the AD field and made recommendations in the areas of genetics, clinical trials, protein aggregation, and the cell biology of the nervous system. We hope these recommendations will boost research progress in AD and increase the likelihood of developing effective therapies in the near future.
阿尔茨海默病（AD）是痴呆症最常见的病因，如果任其发展而不加控制，将引发全球性的公共健康危机。尽管我们在对 AD 的科学认识方面取得了巨大进展，但仍没有有效的方法来延缓、预防或减缓这种疾病。在 2011 年的 Abelson 会议上，一群不同领域的科学家讨论了 AD 领域当前面临的挑战，并在遗传学、临床试验、蛋白质聚集和神经系统的细胞生物学等领域提出了建议。我们希望这些建议将推动 AD 的研究进展，并增加在不久的将来开发有效疗法的可能性。
