Johnsen Erik, Kroken Rune, Løberg Else-Marie, Kjelby Eirik, Jørgensen Hugo A
Division of Psychiatry, Haukeland University Hospital, Sandviksleitet 1, 5035 Bergen, Norway.
Adv Urol. 2011;2011:686924. doi: 10.1155/2011/686924. Epub 2011 Nov 30.
Introduction. Sexual dysfunction (SD) and hyperprolactinemia are frequently reported in patients with psychotic disorders and have the potential for severe complications but investigations in males are particularly scarce. The primary aims were to determine the prevalence of SD and hyperprolactinemia in male patients and to investigate whether associations exist between SD and prolactin levels. Methods. Cross-sectional data were obtained at discharge from the hospital or 6 weeks after admittance for patients acutely admitted for psychosis and treated with a second-generation antipsychotic drug. Results. Half the patients reported diminished sexual desire and more than a third reported erectile and ejaculatory dysfunctions with no differences among the drugs. More than half the sample was hyperprolactinemic. No association was found between prolactin levels and SD. Conclusion. High rates of SD and hyperprolactinemia were found in male patients and should be a treatment target. SD and hyperprolactinemia were not correlated.
引言。性功能障碍(SD)和高催乳素血症在精神病患者中经常被报道,并且有可能引发严重并发症,但针对男性患者的研究尤为稀少。主要目的是确定男性患者中SD和高催乳素血症的患病率,并调查SD与催乳素水平之间是否存在关联。方法。收集因精神病急性入院并接受第二代抗精神病药物治疗的患者出院时或入院6周后的横断面数据。结果。一半的患者报告性欲减退,超过三分之一的患者报告勃起和射精功能障碍,不同药物之间无差异。超过一半的样本存在高催乳素血症。未发现催乳素水平与SD之间存在关联。结论。男性患者中SD和高催乳素血症的发生率较高,应作为治疗靶点。SD与高催乳素血症不相关。