环磷酸腺苷依赖性蛋白激酶和促肾上腺皮质激素（ACTH）敏感的腺苷酸环化酶的突变会影响肾上腺类固醇生成。
Mutations in cyclic AMP-dependent protein kinase and corticotropin (ACTH)-sensitive adenylate cyclase affect adrenal steroidogenesis.
作者信息
Rae P A, Gutmann N S, Tsao J, Schimmer B P
出版信息
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1896-900. doi: 10.1073/pnas.76.4.1896.
Abstract
Two groups of mutant clones were isolated from YI adrenocortical tumor cells. One group, Y1(Kin), exhibited altered cytosolic cyclic AMP-dependent protein kinase activity; the second group, Y1(Cyc), exhibited diminished corticotropin-responsive adenylate cyclase activity. Steroidogenic responses to corticotropin and cyclic nucleotides closely paralleled cyclic AMP-dependent protein kinase activity in the Y1(Kin) mutants. In Y1(Cyc) mutants, corticotropin had little effect on steroidogenesis, whereas cyclic nucleotides were fully active. These data imply that adenylate cyclase and cyclic AMP-dependent protein kinase are obligatory components of the corticotropin-stimulated steroidogenic pathway.
摘要
从YI肾上腺皮质肿瘤细胞中分离出两组突变克隆。一组Y1(Kin)表现出胞质环磷酸腺苷（cAMP）依赖性蛋白激酶活性改变；第二组Y1(Cyc)表现出促肾上腺皮质激素反应性腺苷酸环化酶活性降低。在Y1(Kin)突变体中，对促肾上腺皮质激素和环核苷酸的类固醇生成反应与cAMP依赖性蛋白激酶活性密切平行。在Y1(Cyc)突变体中，促肾上腺皮质激素对类固醇生成几乎没有影响，而环核苷酸则具有完全活性。这些数据表明，腺苷酸环化酶和cAMP依赖性蛋白激酶是促肾上腺皮质激素刺激的类固醇生成途径的必需成分。
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Proc Natl Acad Sci U S A. 1979 Apr;76(4):1896-900. doi: 10.1073/pnas.76.4.1896.
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