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1
The role of protein kinase activation in the control of steroidogenesis by adrenocorticotrophic hormone in the adrenal cortex.蛋白激酶激活在促肾上腺皮质激素对肾上腺皮质类固醇生成控制中的作用。
Biochem J. 1973 Dec;136(4):993-8. doi: 10.1042/bj1360993.
2
Role of cyclic AMP and protein kinase on the steroidogenic action of ACTH, prostaglandin E1 and dibutyryl cyclic AMP in normal adrenal cells and adrenal tumor cells from humans.环磷酸腺苷（cAMP）和蛋白激酶在促肾上腺皮质激素（ACTH）、前列腺素E1及二丁酰环磷酸腺苷对人正常肾上腺细胞和肾上腺肿瘤细胞的类固醇生成作用中的角色。
J Cyclic Nucleotide Res. 1978 Aug;4(4):311-21.
3
Studies on cyclic nucleotides in the adrenal gland. IV. Effect of ACTH on cyclic nucleotides-dependent protein kinases in the adrenal gland.肾上腺中环状核苷酸的研究。IV.促肾上腺皮质激素对肾上腺中环状核苷酸依赖性蛋白激酶的作用。
Endocrinology. 1974 Mar;94(3):650-4. doi: 10.1210/endo-94-3-650.
4
Comparative effects of angiotensin and ACTH on cyclic AMP and steroidogenesis in isolated bovine adrenal cells.血管紧张素和促肾上腺皮质激素对分离的牛肾上腺细胞中环磷酸腺苷及类固醇生成的比较作用
J Clin Invest. 1973 Apr;52(4):835-42. doi: 10.1172/JCI107247.
5
Metabolic regulation and relationship of endogenous protein kinase activity and steroidogenesis in isolated adrenocortical carcinoma cells of the rat.大鼠离体肾上腺皮质癌细胞内源性蛋白激酶活性与类固醇生成的代谢调节及关系
Cancer Res. 1977 Feb;37(2):472-5.
6
Regulation of ornithine decarboxylase activity by corticotropin in adrenocortical tumor cell clones: roles of cyclic AMP and cyclic AMP-dependent protein kinase.促肾上腺皮质激素对肾上腺皮质肿瘤细胞克隆中鸟氨酸脱羧酶活性的调节：环磷酸腺苷和环磷酸腺苷依赖性蛋白激酶的作用
Proc Natl Acad Sci U S A. 1980 May;77(5):2767-71. doi: 10.1073/pnas.77.5.2767.
7
Regulation of adrenal ornithine decarboxylase by adrenocorticotropic hormone and cyclic AMP.促肾上腺皮质激素和环磷酸腺苷对肾上腺鸟氨酸脱羧酶的调节
J Clin Invest. 1973 Aug;52(8):2007-15. doi: 10.1172/JCI107385.
8
Metabolic regulation of steroidogenesis in isolated adrenal cells of rat. Relationship of adrenocorticotropin-, adenosine 3':5'-monophosphate-and guanosine 3':5'-monophosphate-stimulated steroidogenesis with the activation of protein kinase.大鼠分离肾上腺细胞中类固醇生成的代谢调节。促肾上腺皮质激素、3':5'-环磷酸腺苷和3':5'-环磷酸鸟苷刺激的类固醇生成与蛋白激酶激活之间的关系。
Eur J Biochem. 1976 Nov 15;70(2):427-33. doi: 10.1111/j.1432-1033.1976.tb11033.x.
9
On the mechanism of action of cholera toxin on isolated rat adrenocortical cells. Comparison with the effects of adrenocorticotropin on steroidogenesis and cyclic AMP output.霍乱毒素对离体大鼠肾上腺皮质细胞的作用机制。与促肾上腺皮质激素对类固醇生成和环磷酸腺苷生成的影响相比较。
Biochim Biophys Acta. 1975 Oct 9;404(2):221-30. doi: 10.1016/0304-4165(75)90328-1.
10
Salt-inducible kinase is involved in the ACTH/cAMP-dependent protein kinase signaling in Y1 mouse adrenocortical tumor cells.盐诱导激酶参与Y1小鼠肾上腺皮质肿瘤细胞中促肾上腺皮质激素/环磷酸腺苷依赖性蛋白激酶信号传导。
Mol Endocrinol. 2001 Aug;15(8):1264-76. doi: 10.1210/mend.15.8.0675.

引用本文的文献

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ACTH-Modulated Membrane Guanylate Cyclase Signaling System: Origin and Creation.促肾上腺皮质激素调节的膜鸟苷酸环化酶信号系统：起源与产生
Front Mol Neurosci. 2022 Aug 9;15:929396. doi: 10.3389/fnmol.2022.929396. eCollection 2022.
2
ACTH induces Cav3.2 current and mRNA by cAMP-dependent and cAMP-independent mechanisms.ACTH 通过 cAMP 依赖和非依赖机制诱导 Cav3.2 电流和 mRNA。
J Biol Chem. 2010 Jun 25;285(26):20040-50. doi: 10.1074/jbc.M110.104190. Epub 2010 Apr 27.
3
cAMP analogs and their metabolites enhance TREK-1 mRNA and K+ current expression in adrenocortical cells.cAMP 类似物及其代谢产物可增强肾上腺皮质细胞中 TREK-1 mRNA 和 K+ 电流的表达。
Mol Pharmacol. 2010 Mar;77(3):469-82. doi: 10.1124/mol.109.061861. Epub 2009 Dec 22.
4
ACTH inhibits bTREK-1 K+ channels through multiple cAMP-dependent signaling pathways.促肾上腺皮质激素通过多种环磷酸腺苷（cAMP）依赖性信号通路抑制双孔钾通道-1（bTREK-1）。
J Gen Physiol. 2008 Aug;132(2):279-94. doi: 10.1085/jgp.200810003.
5
Mutations in cyclic AMP-dependent protein kinase and corticotropin (ACTH)-sensitive adenylate cyclase affect adrenal steroidogenesis.环磷酸腺苷依赖性蛋白激酶和促肾上腺皮质激素（ACTH）敏感的腺苷酸环化酶的突变会影响肾上腺类固醇生成。
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1896-900. doi: 10.1073/pnas.76.4.1896.
6
Adenosine 3':5'-cyclic monophosphate-dependent protein kinase(s) of rat ovarian cells. Gonadotropin regulation of adenosine 3':5'-cyclic monophosphate-receptor activity.大鼠卵巢细胞的3':5'-环磷酸腺苷依赖性蛋白激酶。促性腺激素对3':5'-环磷酸腺苷受体活性的调节。
Biochem J. 1978 Jun 15;172(3):433-42. doi: 10.1042/bj1720433.
7
Correlation of protein kinase activation and testosterone production after stimulation of Leydig cells with luteinizing hormone.促黄体生成素刺激睾丸间质细胞后蛋白激酶激活与睾酮生成的相关性。
Biochem J. 1976 Dec 15;160(3):439-46. doi: 10.1042/bj1600439.
8
Ovarian adenosine 3':5'-cyclic monophosphate-dependent protein kinase(s). Regulation by choriogonadotropin and lutropin in rat ovarian cells.卵巢3':5'-环磷酸腺苷依赖性蛋白激酶。大鼠卵巢细胞中促性腺激素释放激素和促黄体生成素的调节作用。
Biochem J. 1976 Aug 15;158(2):175-82. doi: 10.1042/bj1580175.
9
Protein kinase activity in rat testis interstitial tissue. Effect of luteinizing hormone and other factors.大鼠睾丸间质组织中的蛋白激酶活性。促黄体生成素及其他因素的影响。
Biochem J. 1976 Feb 15;154(2):371-8. doi: 10.1042/bj1540371.
10
Hormonal modulation of cyclic adenosine 3',5'-monophosphate-dependent protein kinase activity in rat renal cortex. Specificity of enzyme translocation.大鼠肾皮质中3',5'-环磷酸腺苷依赖性蛋白激酶活性的激素调节。酶转位的特异性。
J Clin Invest. 1976 Jun;57(6):1442-50. doi: 10.1172/JCI108414.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Adenosine 3',5'-monophosphate as the intracellular mediator of the action of adrenocorticotropic hormone on the adrenal cortex.3',5'-环磷酸腺苷作为促肾上腺皮质激素作用于肾上腺皮质的细胞内介质。
J Biol Chem. 1967 Dec 10;242(23):5535-41.
3
Kinetics and dose-response characteristics of adenosine 3',5'-monophosphate production by isolated rat adrenal cells stimulated with adrenocorticotrophic hormone.促肾上腺皮质激素刺激的离体大鼠肾上腺细胞产生3',5'-单磷酸腺苷的动力学和剂量反应特征
FEBS Lett. 1972 Jul 1;23(3):345-348. doi: 10.1016/0014-5793(72)80312-0.
4
The mode of action of adenosine 3':5'-cyclic monophosphate in mammalian islets of Langerhans. Effects of insulin secretagogues on islet-cell protein kinase activity.3':5'-环磷酸腺苷在哺乳动物胰岛中的作用方式。胰岛素促分泌剂对胰岛细胞蛋白激酶活性的影响。
Biochem J. 1973 May;134(1):321-7. doi: 10.1042/bj1340321.
5
Phosphodiesterase activity and the potentiation by theophylline of adrenocorticotrophin stimulated steroidogenesis and adenosine 3',5'-monophosphate levels in isolated rat adrenal cells.磷酸二酯酶活性以及茶碱对促肾上腺皮质激素刺激的离体大鼠肾上腺细胞中类固醇生成和3',5'-环磷酸腺苷水平的增强作用。
Biochem Biophys Res Commun. 1973 Jul 17;53(2):545-51. doi: 10.1016/0006-291x(73)90696-7.
6
Corticosteroidogenesis in isolated adrenal cells: effect of adrenocorticotrophic hormone, adenosine 3',5'-monophosphate and 1-24 adrenocorticotrophic hormone diazotized to polyacrylamide.分离肾上腺细胞中的皮质类固醇生成：促肾上腺皮质激素、3',5'-单磷酸腺苷及偶联到聚丙烯酰胺上的1-24促肾上腺皮质激素的作用
J Endocrinol. 1972 Oct;55(1):127-39. doi: 10.1677/joe.0.0550127.
7
Comparison of steroidogenic effects of cAMP and dbcAMP in the rat adrenal gland.环磷酸腺苷（cAMP）和双丁酰环磷腺苷（dbcAMP）对大鼠肾上腺皮质激素生成作用的比较
Endocrinology. 1973 Mar;92(3):679-86. doi: 10.1210/endo-92-3-679.
8
Steroidogenesis and cyclic adenosine 3',5'-monophosphate accumulation in rat adrenal cells. Divergent effects of adrenocorticotropin and its o-nitrophenyl sulfenyl derivative.大鼠肾上腺细胞中的类固醇生成及环磷酸腺苷积累。促肾上腺皮质激素及其邻硝基苯硫基衍生物的不同作用。
J Biol Chem. 1973 Apr 10;248(7):2409-17.
9
Cyclic adenosine 3',5'-monophosphate-dependent protein kinase of human erythrocyte membranes.人红细胞膜的环腺苷酸依赖性蛋白激酶
J Biol Chem. 1972 Oct 10;247(19):6135-9.
10
Phosphorylation of an endogenous membrane protein by an endogenous, membrane-associated cyclic adenosine 3',5'-monophosphate-dependent protein kinase in human erythrocyte ghosts.人红细胞血影中一种内源性膜相关环磷酸腺苷依赖性蛋白激酶对一种内源性膜蛋白的磷酸化作用。
J Biol Chem. 1972 Dec 25;247(24):8145-53.

蛋白激酶激活在促肾上腺皮质激素对肾上腺皮质类固醇生成控制中的作用。

The role of protein kinase activation in the control of steroidogenesis by adrenocorticotrophic hormone in the adrenal cortex.

作者信息

Richardson M C, Schulster D

出版信息

Biochem J. 1973 Dec;136(4):993-8. doi: 10.1042/bj1360993.

DOI:10.1042/bj1360993
PMID:4362338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1166049/
Abstract

A method has been developed for investigation of the effect of adrenocorticotrophic hormone (ACTH) on the state of activation of a cyclic AMP-dependent protein kinase within cells of the adrenal cortex. Enzyme activity was measured in terms of the quantity of (32)P transferred from [gamma-(32)P]ATP to histone under conditions in which bound cyclic AMP did not dissociate from the regulatory subunit of the protein kinase ACTH (1x10(-2)i.u./ml) caused a rapid and complete activation of the cyclic AMP-dependent protein kinase activity within 2min of hormone addition to the isolated cells. In response to a range of ACTH concentrations a sigmoid log dose-response curve for protein kinase activation was obtained, with half-maximal stimulation attained at about 1x10(-3)i.u./ml. However, some low doses of ACTH that elicited a marked (but submaximal) steroidogenic response failed to cause a clear stimulation of protein kinase activity in isolated adrenal cells. Theophylline (2mm) potentiated the effect of ACTH on protein kinase activity. The results implicate an important role for protein kinase in ACTH action on the adrenocortical cell.

摘要

已开发出一种方法，用于研究促肾上腺皮质激素（ACTH）对肾上腺皮质细胞内依赖环磷酸腺苷（cAMP）的蛋白激酶激活状态的影响。在结合的cAMP不会从蛋白激酶的调节亚基解离的条件下，通过测量从[γ-(32)P]ATP转移到组蛋白上的(32)P的量来测定酶活性。将ACTH（1×10(-2)国际单位/毫升）添加到分离的细胞中后，在2分钟内即可快速且完全激活依赖cAMP的蛋白激酶活性。对于一系列ACTH浓度，获得了蛋白激酶激活的S形对数剂量反应曲线，在约1×10(-3)国际单位/毫升时达到最大刺激的一半。然而，一些能引发显著（但未达到最大）类固醇生成反应的低剂量ACTH未能在分离的肾上腺细胞中引起蛋白激酶活性的明显刺激。茶碱（2毫摩尔）增强了ACTH对蛋白激酶活性的作用。结果表明蛋白激酶在ACTH对肾上腺皮质细胞的作用中起重要作用。