Christensen Eidi, Mørk Cato, Foss Olav Andreas
Department of Dermatology, St. Olav's University Hospital HF, Institute of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), 7030 Trondheim, Norway.
J Skin Cancer. 2011;2011:240340. doi: 10.1155/2011/240340. Epub 2011 Nov 15.
Topical photodynamic therapy (PDT) has limitations in the treatment of thick skin tumours. The aim of the study was to evaluate the effect of pre-PDT deep curettage on tumour thickness in thick (≥2 mm) basal cell carcinoma (BCC). Additionally, 3-month treatment outcome and change of tumour thickness from diagnosis to treatment were investigated. At diagnosis, mean tumour thickness was 2.3 mm (range 2.0-4.0). Pre- and post-curettage biopsies were taken from each tumour prior to PDT. Of 32 verified BCCs, tumour thickness was reduced by 50% after deep curettage (P ≤ 0.001). Mean tumour thickness was also reduced from diagnosis to treatment. At 3-month followup, complete tumour response was found in 93% and the cosmetic outcome was rated excellent or good in 100% of cases. In conclusion, deep curettage significantly reduces BCC thickness and may with topical PDT provide a favourable clinical and cosmetic short-term outcome.
局部光动力疗法（PDT）在治疗厚皮肿瘤方面存在局限性。本研究的目的是评估 PDT 前深部刮除术对厚（≥2 毫米）基底细胞癌（BCC）肿瘤厚度的影响。此外，还研究了 3 个月的治疗结果以及从诊断到治疗期间肿瘤厚度的变化。诊断时，平均肿瘤厚度为 2.3 毫米（范围 2.0 - 4.0）。在 PDT 之前，从每个肿瘤取刮除术前和术后的活检样本。在 32 例经证实的 BCC 中，深部刮除术后肿瘤厚度减少了 50%（P≤0.001）。从诊断到治疗，平均肿瘤厚度也有所降低。在 3 个月的随访中，93%的患者肿瘤完全缓解，100%的病例美容效果评为优秀或良好。总之，深部刮除术显著降低了 BCC 的厚度，并且与局部 PDT 联合使用可能提供良好的短期临床和美容效果。
