Mohamadin Ahmed M, Elberry Ahmed A, Abdel Gawad Hala S, Morsy Gehan M, Al-Abbasi Fahad A
Department of Chemistry for Health Sciences, Deanery of Academic Services, Health Sciences Track, Taibah University, Al-Madinah, Saudi Arabia.
J Lipids. 2011;2011:167958. doi: 10.1155/2011/167958. Epub 2011 Dec 6.
The present study was undertaken to evaluate the possible protective effects of simvastatin (SMV) against oxidative stress in streptozotocin- (STZ)-induced diabetic rats. Diabetes was induced experimentally in rats by i.p. injection of STZ in a dose of 60 mg/kg bwt. After 5 weeks of STZ injection, there were apparent reductions in the animal body weight and significant increase in blood glucose, HbA1(c), urea, creatinine, AST, ALT, and lipid profiles with a concomitant decrease in total hemoglobin, plasma glutathione and vitamin C as compared to the control group. The treatment with SMV at a dose (10 mg/kg, orally) normalized all the above-mentioned biochemical parameters in STZ-induced diabetic rats. In vitro studies confirmed the free radical scavenging and antioxidant activity of SMV. Therefore, the present results revealed that SMV has a protective effect against STZ-induced oxidative damage by scavenging the free radicals generation and restoring the enzymatic and nonenzymatic antioxidant systems.
本研究旨在评估辛伐他汀（SMV）对链脲佐菌素（STZ）诱导的糖尿病大鼠氧化应激的可能保护作用。通过腹腔注射60mg/kg体重的STZ在大鼠中实验性诱导糖尿病。STZ注射5周后，与对照组相比，动物体重明显降低，血糖、糖化血红蛋白（HbA1c）、尿素、肌酐、谷草转氨酶（AST）、谷丙转氨酶（ALT）和血脂水平显著升高，同时总血红蛋白、血浆谷胱甘肽和维生素C降低。以10mg/kg口服剂量的SMV治疗使STZ诱导的糖尿病大鼠的所有上述生化参数恢复正常。体外研究证实了SMV的自由基清除和抗氧化活性。因此，本研究结果表明，SMV通过清除自由基生成并恢复酶促和非酶促抗氧化系统，对STZ诱导的氧化损伤具有保护作用。
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