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白藜芦醇和红酒在实验性糖尿病中具有神经保护作用，作为抗氧化剂，它们没有细胞增殖作用。

Resveratrol and red wine function as antioxidants in the nervous system without cellular proliferative effects during experimental diabetes.

机构信息

Universidade Federal de Ciências da Saúde de Porto Alegre, Division of Pharmacology, Porto Alegre, Brazil.

出版信息

Oxid Med Cell Longev. 2010 Nov-Dec;3(6):434-41. doi: 10.4161/oxim.3.6.14741. Epub 2010 Nov 1.

DOI:10.4161/oxim.3.6.14741
PMID:21307644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3154048/
Abstract

Chronic hyperglycemia increases oxidative stress status and has been associated with neurological complications in diabetic individuals. This study compared the antioxidant properties of red wine or resveratrol in different brain areas of diabetic and non-diabetic rats, and investigated the effect of them on hippocampal cell proliferation in hippocampal dentate gyrus of diabetic rats. Streptozotocin-induced diabetic and control rats were treated with red wine (4 mL/kg), resveratrol (20 mg/kg), or saline, by oral gavage, for 21 days. Lipid peroxidation (TBARS), catalase and superoxide dismutase were measured to evaluate the oxidative stress and the BrdU-positive cells were assessed to measure changes in cellular proliferation. In diabetic animals, resveratrol showed antioxidant property in the hippocampus and in the striatum, while red wine had an antioxidant effect only in the hippocampus. Neither red wine nor resveratrol reversed the lower hippocampal cell proliferation in diabetic rats. Daily doses of red wine or resveratrol have an antioxidant effect in rats depending on the brain area and the glycemic status.

摘要

慢性高血糖会增加氧化应激状态，并与糖尿病患者的神经并发症有关。本研究比较了红葡萄酒或白藜芦醇在糖尿病和非糖尿病大鼠不同脑区的抗氧化特性，并研究了它们对糖尿病大鼠海马齿状回中海马细胞增殖的影响。链脲佐菌素诱导的糖尿病和对照大鼠通过口服灌胃接受红葡萄酒（4 毫升/千克）、白藜芦醇（20 毫克/千克）或生理盐水治疗 21 天。测量脂质过氧化（TBARS）、过氧化氢酶和超氧化物歧化酶来评估氧化应激，并用 BrdU 阳性细胞评估细胞增殖的变化。在糖尿病动物中，白藜芦醇在海马和纹状体中表现出抗氧化特性，而红葡萄酒仅在海马中具有抗氧化作用。红葡萄酒和白藜芦醇都没有逆转糖尿病大鼠海马细胞增殖减少的现象。红葡萄酒或白藜芦醇的每日剂量根据大脑区域和血糖状况在大鼠中具有抗氧化作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df80/3154048/c97d4c68d093/OXIMED3-568184_434.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df80/3154048/3329342a7e67/OXIMED3-568184_434.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df80/3154048/7b7109d44dfc/OXIMED3-568184_434.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df80/3154048/535305d3f498/OXIMED3-568184_434.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df80/3154048/c97d4c68d093/OXIMED3-568184_434.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df80/3154048/3329342a7e67/OXIMED3-568184_434.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df80/3154048/7b7109d44dfc/OXIMED3-568184_434.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df80/3154048/535305d3f498/OXIMED3-568184_434.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df80/3154048/c97d4c68d093/OXIMED3-568184_434.004.jpg

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